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Abnova
MAPRE1 Monoclonal Antibody (4F3)
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Product Details
H00022919-M02
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4F3
Immunogen
MAPRE1 (NP_036457, 1 a.a. approximately 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: MAVNVYSTSV TSDNLSRHDM LAWINESLQL NLTKIEQLCS GAAYCQFMDM LFPGSIALKK VKFQAKLEHE YIQNFKILQA GFKRMGVDKI IPVDKLVKGK FQDNFEFVQW
Target Information
EB1 family proteins are evolutionarily conserved proteins that bind microtubule plus-ends and centrosomes and regulate the dynamics and organization of microtubules. The MAPRE genes encode the EB1 family proteins. The human MAPRE genes MAPRE1, MAPRE2, and MAPRE3 code for EB1, RP1, and EBF3 proteins, respectively. EB1 family members appear to be expressed ubiquitously. The EB1 (MAPRE1) gene, at 20q11. 2, is fused to MLL in an adult patient with pro-B acute lymphoblastic leukemia. EB1 is a microtubule-associated protein that interacts with the colorectal adenomatous polyposis coli tumor-suppressor protein and plays important roles in regulating microtubule dynamics, cell polarity, and chromosome stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adenomatous polyposis coli-binding protein EB1; APC-binding protein EB1; EB1; End-binding protein 1; MGC117374; MGC129946; Microtubule-associated protein RP/EB family member 1; microtubule-associated protein, RP/EB family, member 1
Gene Aliases: EB1; MAPRE1
UniProt ID: (Human) Q15691
Entrez Gene ID: (Human) 22919
G2/M transition of mitotic cell cycle
sister chromatid cohesion
mitotic nuclear division
cell proliferation
positive regulation of cell migration
negative regulation of microtubule polymerization
protein localization to microtubule
cell division
cell-cell adhesion
positive regulation of microtubule plus-end binding
negative regulation of microtubule binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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