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Product Details
H00004082-M06
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
2C2
Immunogen
MARCKS (NP_002347, 2 a.a. approximately 65 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: GAQFSKTAAK GEAAAERPGE AAVASSPSKA NGQENGHVKV NGDASPAAAE SGAKEELQAN GSAP
Target Information
MARCKS is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 80K protein; 80K-L protein; FLJ14368; FLJ90045; MARCKS; MARCS; Myristoylated alanine-rich C-kinase substrate; myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L); phosphomyristin; Protein kinase C substrate, 80 kDa protein, light chain
Gene Aliases: 80K-L; MACS; MARCKS; PKCSL; PRKCSL
UniProt ID: (Human) P29966, (Mouse) P26645
Entrez Gene ID: (Human) 4082, (Mouse) 17118
ventricular cardiac muscle tissue development
intracellular protein transport
actin filament organization
brain development
activation of phospholipase D activity
cell-substrate adhesion
regulation of insulin secretion
positive regulation of dendritic spine morphogenesis
positive regulation of protein kinase C activity
positive regulation of glucose import in response to insulin stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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