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MARK4 Polyclonal Antibody

MARK4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MARK4 Antibody (20174-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human testis tissue slide using 20174-1-AP (MARK4 Antibody) at dilution of 1:200 (under 40x lens).

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Product Details

20174-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MARK4 Fusion Protein Ag14013 (627-751 aa encoded by BC009049)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VADEPERIG GPEVTSCHLP WDQTETAPRL LRFPWSVKLT SSRPPEALMA ALRQATAAAR CRCRQPQPFL LACLHGGAGG PEPLSHFEVE VCQLPRPGLR GVLFRRVAGT ALAFRTLVTR ISNDLE (627-751 aa encoded by BC009049)

Target Information

MARK4 is a serine/threonine kinase that is likely to be directly involved in microtubule organization in neuronal cells. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of MARK4 is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of MARK4 are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for MARK4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.

Endocrinology

Tang EI,Cheng CY

Tue Oct 11 00:00:00 UTC 2022

MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons.

Endocrinology

Tang EI,Cheng CY

Tue Oct 11 00:00:00 UTC 2022

Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis.

Journal of oral microbiology

Wang L,Pu W,Wang C,Lei L,Li H

Fri Apr 29 00:00:00 UTC 2022

The Non-hormonal Male Contraceptive Adjudin Exerts its Effects via MAPs and Signaling Proteins mTORC1/rpS6 and FAK-Y407.

Endocrinology

Wang L,Yan M,Li H,Wu S,Ge R,Wong CKC,Silvestrini B,Sun F,Cheng CY

Fri Jan 01 00:00:00 UTC 2021

KIF15 supports spermatogenesis via its effects on Sertoli cell microtubule, actin, vimentin, and septin cytoskeletons.

Endocrinology

Wu S,Lv L,Li L,Wang L,Mao B,Li J,Shen X,Ge R,Wong CKC,Sun F,Cheng CY

Thu Apr 01 00:00:00 UTC 2021

KIF15 supports spermatogenesis via its effects on Sertoli cell microtubule, actin, vimentin, and septin cytoskeletons.

Endocrinology

Wu S,Lv L,Li L,Wang L,Mao B,Li J,Shen X,Ge R,Wong CKC,Sun F,Cheng CY

Thu Apr 01 00:00:00 UTC 2021

NC1-Peptide From Collagen α3 (IV) Chains in the Basement Membrane of Testes Regulates Spermatogenesis via p-FAK-Y407.

Endocrinology

Li H,Liu S,Wu S,Ge R,Cheng CY

Thu Oct 01 00:00:00 UTC 2020

Endogenously produced LG3/4/5-peptide protects testes against toxicant-induced injury.

Cell death & disease

Li L,Mao B,Wu S,Li H,Lv L,Ge R,Cheng CY

Mon Jun 08 00:00:00 UTC 2020

NC1-peptide regulates spermatogenesis through changes in cytoskeletal organization mediated by EB1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Liu S,Li H,Wu S,Li L,Ge R,Cheng CY

Sat Feb 01 00:00:00 UTC 2020

NC1-peptide regulates spermatogenesis through changes in cytoskeletal organization mediated by EB1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Liu S,Li H,Wu S,Li L,Ge R,Cheng CY

Sat Feb 01 00:00:00 UTC 2020

Cdc42 is involved in NC1 peptide-regulated BTB dynamics through actin and microtubule cytoskeletal reorganization.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Su W,Cheng CY

Sun Dec 01 00:00:00 UTC 2019

CAMSAP2 Is a Microtubule Minus-End Targeting Protein That Regulates BTB Dynamics Through Cytoskeletal Organization.

Endocrinology

Mao BP,Li L,Ge R,Li C,Wong CKC,Silvestrini B,Lian Q,Cheng CY

Sat Jun 01 00:00:00 UTC 2019

F5-Peptide and mTORC1/rpS6 Effectively Enhance BTB Transport Function in the Testis-Lesson From the Adjudin Model.

Endocrinology

Mao B,Li L,Yan M,Wong CKC,Silvestrini B,Li C,Ge R,Lian Q,Cheng CY

Thu Aug 01 00:00:00 UTC 2019

Regulation of BTB Dynamics in Spermatogenesis-Insights From the Adjudin Model.

Toxicological sciences : an official journal of the Society of Toxicology

Mao BP,Li L,Yan M,Ge R,Lian Q,Cheng CY

Fri Nov 01 00:00:00 UTC 2019

Regulation of the blood-testis barrier by a local axis in the testis: role of laminin α2 in the basement membrane.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Gao Y,Mruk D,Chen H,Lui WY,Lee WM,Cheng CY

Wed Feb 01 00:00:00 UTC 2017

Regulation of the blood-testis barrier by a local axis in the testis: role of laminin α2 in the basement membrane.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Gao Y,Mruk D,Chen H,Lui WY,Lee WM,Cheng CY

Wed Feb 01 00:00:00 UTC 2017

Basement Membrane Laminin α2 Regulation of BTB Dynamics via Its Effects on F-Actin and Microtubule Cytoskeletons Is Mediated Through mTORC1 Signaling.

Endocrinology

Gao Y,Chen H,Lui WY,Lee WM,Cheng CY

Sat Apr 01 00:00:00 UTC 2017

Sperm Release at Spermiation Is Regulated by Changes in the Organization of Actin- and Microtubule-Based Cytoskeletons at the Apical Ectoplasmic Specialization-A Study Using the Adjudin Model.

Endocrinology

Li L,Tang EI,Chen H,Lian Q,Ge R,Silvestrini B,Cheng CY

Fri Dec 01 00:00:00 UTC 2017

Sperm Release at Spermiation Is Regulated by Changes in the Organization of Actin- and Microtubule-Based Cytoskeletons at the Apical Ectoplasmic Specialization-A Study Using the Adjudin Model.

Endocrinology

Li L,Tang EI,Chen H,Lian Q,Ge R,Silvestrini B,Cheng CY

Fri Dec 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: FLJ90097; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase like 1; MAP/microtubule affinity-regulating kinase-like 1; MARK4 serine/threonine protein kinase; Nbla00650

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Gene Aliases: KIAA1860; MARK4; MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D

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UniProt ID: (Human) Q96L34

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Entrez Gene ID: (Human) 57787

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Function(s)

protein serine/threonine kinase activity protein binding ATP binding microtubule binding gamma-tubulin binding ubiquitin binding tau-protein kinase activity

Process(es)

microtubule cytoskeleton organization microtubule bundle formation protein phosphorylation mitotic nuclear division nervous system development establishment of cell polarity cell projection organization positive regulation of programmed cell death cell division

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MARK4 Polyclonal Antibody

MARK4 Antibody (20174-1-AP) in IHC (P)

Product Details

20174-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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