Proteintech

MAX Polyclonal Antibody

MAX Antibody in Immunocytochemistry (ICC/IF)

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MAX Antibody (10426-1-AP) in ICC/IF

Immunofluorescent analysis of PC-3 cells using 10426-1-AP (MAX antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

MAX Antibody in Immunoprecipitation (IP)

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Product Details

10426-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

ChIP assay (ChIP)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MAX Fusion Protein Ag0680 (1-151 aa encoded by BC003525)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Bands recognized by this antibody are much larger than predicted.

Immunogen sequence: MSDNDDIEV ESDADKRAHH NALERKRRDH IKDSFHSLRD SVPSLQGEKA SRAQILDKAT EYIQYMRRKN HTHQQDIDDL KRQNALLEQQ VRALEKARSS AQLQTNYPSS DNSLYTNAKG STISAFDGGS DSSSESEPEE PQSRKKLRME AS (1-151 aa encoded by BC003525)

Target Information

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature for some of them is unknown.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A program of successive gene expression in mouse one-cell embryos.

Cell reports

Asami M,Lam BYH,Hoffmann M,Suzuki T,Lu X,Yoshida N,Ma MK,Rainbow K,Gužvić M,VerMilyea MD,Yeo GSH,Klein CA,Perry ACF

Tue Feb 28 00:00:00 UTC 2023

PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression.

Nature communications

Lan X,Ding S,Zhang T,Yi Y,Li C,Jin W,Chen J,Liang K,Wang H,Jiang W

Sat Aug 06 00:00:00 UTC 2022

Integrated analysis of mRNA-seq and miRNA-seq reveals the potential roles of Egr1, Rxra and Max in kidney stone disease.

Urolithiasis

Huang L,Shi Y,Hu J,Ding J,Guo Z,Yu B

Fri Dec 09 00:00:00 UTC 2022

MAX deficiency impairs human endometrial decidualization through down-regulating OSR2 in women with recurrent spontaneous abortion.

Cell and tissue research

Ma W,Cao M,Bi S,Du L,Chen J,Wang H,Jiang Y,Wu Y,Liao Y,Kong S,Liu J

Sun May 01 00:00:00 UTC 2022

A MYC inhibitor selectively alters the MYC and MAX cistromes and modulates the epigenomic landscape to regulate target gene expression.

Science advances

Holmes AG,Parker JB,Sagar V,Truica MI,Soni PN,Han H,Schiltz GE,Abdulkadir SA,Chakravarti D

Fri Apr 29 00:00:00 UTC 2022

Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability.

Cell communication and signaling : CCS

Yao R,Zhang M,Zhou J,Liu L,Zhang Y,Gao J,Xu K

Thu May 26 00:00:00 UTC 2022

NAD⁺ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells.

Cell reports

Wang Y,Wang F,Wang L,Qiu S,Yao Y,Yan C,Xiong X,Chen X,Ji Q,Cao J,Gao G,Li D,Zhang L,Guo Z,Wang R,Wang H,Fan G

Tue Aug 10 00:00:00 UTC 2021

Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness.

eLife

Mathsyaraja H,Catchpole J,Freie B,Eastwood E,Babaeva E,Geuenich M,Cheng PF,Ayers J,Yu M,Wu N,Moorthi S,Poudel KR,Koehne A,Grady W,Houghton AM,Berger AH,Shiio Y,MacPherson D,Eisenman RN

Thu Jul 08 00:00:00 UTC 2021

Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness.

eLife

Mathsyaraja H,Catchpole J,Freie B,Eastwood E,Babaeva E,Geuenich M,Cheng PF,Ayers J,Yu M,Wu N,Moorthi S,Poudel KR,Koehne A,Grady W,Houghton AM,Berger AH,Shiio Y,MacPherson D,Eisenman RN

Thu Jul 08 00:00:00 UTC 2021

Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1.

The Journal of biological chemistry

Long J,Galvan DL,Mise K,Kanwar YS,Li L,Poungavrin N,Overbeek PA,Chang BH,Danesh FR

Fri Nov 20 00:00:00 UTC 2020

MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer.

Cancer cell

Augert A,Mathsyaraja H,Ibrahim AH,Freie B,Geuenich MJ,Cheng PF,Alibeckoff SP,Wu N,Hiatt JB,Basom R,Gazdar A,Sullivan LB,Eisenman RN,MacPherson D

Mon Jul 13 00:00:00 UTC 2020

Myc/Max dependent intronic long antisense noncoding RNA, EVA1A-AS, suppresses the expression of Myc/Max dependent anti-proliferating gene EVA1A in a U2 dependent manner.

Scientific reports

Niehus SE,Allister AB,Hoffmann A,Wiehlmann L,Tamura T,Tran DDH

Thu Nov 21 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: bHLHd4; Class D basic helix-loop-helix protein 4; Delta-Max; MGC10775; MGC11225; MGC18164; MGC34679; MGC36767; Myc-associated factor X; Myc-binding novel HLH/LZ protein; orf1; Protein max; Protein myn

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Gene Aliases: AA960152; AI875693; BHLHD4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; MAX; Myn

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UniProt ID: (Human) P61244, (Mouse) P28574

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Entrez Gene ID: (Human) 4149, (Mouse) 17187

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter sequence-specific transcription factor activity, sequence-specific DNA binding transcription cofactor activity transcription coactivator activity protein binding protein complex binding protein homodimerization activity protein heterodimerization activity DNA binding sequence-specific DNA binding protein dimerization activity

Process(es)

regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein complex assembly cellular response to starvation negative regulation of gene expression response to insulin response to axon injury neuron apoptotic process retina development in camera-type eye cellular response to peptide hormone stimulus transcription, DNA-templated regulation of transcription, DNA-templated

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MAX Polyclonal Antibody

MAX Antibody (10426-1-AP) in ICC/IF

Product Details

10426-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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