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Proteintech
MAdCAM1 Monoclonal Antibody (2A12E8)
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Product Details
66594-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2A12E8
Immunogen
MAdCAM1 Fusion Protein Ag16184 (24-343 aa encoded by BC142629)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KPLQVEPPE PVVAVALGAS RQLTCRLACA DRGASVQWRG LDTSLGAVQS DTGRSVLTVR NASLSAAGTR VCVGSCGGRT FQHTVQLLVY AFPDQLTVSP AALVPGDPEV ACTAHKVTPV DPNALSFSLL VGGQELEGAQ ALGPEVQEEE EEPQGDEDVL FRVTERWRLP PLGTPVPPAL YCQATMRLPG LELSHRQAIP VLHSPTSPEP PDTTSPEPPN TTSPESPDTT SPESPDTTSQ EPPDTTSQEP PDTTSQEPPD TTSPEPPDKT SPEPAPQQGS THTPRSPGST RTRRPEISQA GPTQGEVIPT GSSKPAGDQL P (24-343 aa encoded by BC142629)
Target Information
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hMAdCAM-1; MAdCAM-1; Mucosal addressin cell adhesion molecule 1; mucosal addressin cell adhesion molecule-1
Gene Aliases: MACAM1; MADCAM1
UniProt ID: (Human) Q13477
Entrez Gene ID: (Human) 8174
positive regulation of leukocyte migration
immune response
cell adhesion
cell-matrix adhesion
signal transduction
integrin-mediated signaling pathway
aging
extracellular matrix organization
heterotypic cell-cell adhesion
receptor clustering
regulation of immune response
leukocyte tethering or rolling
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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