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Product Details
MA5-49067
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
14D12
Immunogen
Purified MBL-C
Conjugate
Form
Liquid
Concentration
100 µg/mL
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3091116
Product Specific Information
The monoclonal antibody 14D12 is a calcium-dependent antibody.
Target Information
MBL2 is a calcium-dependent lectin involved in innate immune defense. It binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. It also binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. MBL2 may bind DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Collectin1; Mannan-binding protein; mannose binding lectin (C); mannose binding lectin, liver (C); Mannose-binding protein C; MBP-C; MBPC; MGC116832; MGC116833; RA-reactive factor P28A subunit; RARF/P28A
Gene Aliases: L-MBP; MBL; MBL-C; Mbl2; MBP-C
UniProt ID: (Mouse) P41317
Entrez Gene ID: (Mouse) 17195
complement activation, lectin pathway
immune system process
complement activation, classical pathway
negative regulation of growth of symbiont in host
innate immune response
negative regulation of viral process
positive regulation of phagocytosis
defense response to Gram-positive bacterium
killing by host of symbiont cells
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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