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Invitrogen
MBNL3 Isoform G Polyclonal Antibody
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Product Details
PA5-21836
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human MBNL3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.92 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11155432
Product Specific Information
Recommended positive controls: 293T, A431, HeLaS3, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (86%), Rat (87%), Bovine (87%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
MBNL3 (Muscleblind-like protein 3) is an RNA-binding protein involved in the regulation of alternative splicing. The gene encodes several isoforms, including MBNL3 isoform G, which has distinct roles in RNA metabolism and splicing. MBNL3 isoform G contains functional domains necessary for RNA binding and splicing regulation, which are separate from its RNA-binding zinc finger domains. The expression of MBNL3 is particularly noted in proliferating cells where it can inhibit the transcription of muscle-specific genes, thereby impacting myogenesis. This isoform has also been implicated in the regulation of muscle regeneration; knockout models of MBNL3 show impaired muscle regeneration and delayed response to injury. The nuanced regulation by MBNL3 isoform G suggests its importance in muscle biology and its involvement in RNA processing complexities that underpin muscle development and repair.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cys3His CCG1-required protein; muscleblind-like 3; Muscleblind-like protein 3; muscleblind-like splicing regulator 3; Muscleblind-like X-linked protein; Protein HCHCR; RP5-842K24.3
Gene Aliases: CHCR; MBLX; MBLX39; MBNL3; MBXL
UniProt ID: (Human) Q9NUK0
Entrez Gene ID: (Human) 55796
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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