Invitrogen

MBP Monoclonal Antibody (14)

1 Published Figure

8 References

View all (65) MBP antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Published Figures (1)

MBP Antibody in Immunohistochemistry (IHC)

FIGURE: 1 / 1

MBP Antibody (MA1-24990) in IHC

British journal of cancer 2023 - Th2 cell administration enhances innate immune cell activity in gastrointestinal cancers. The expression of Mbp , Mpo and Nos2 ( a ) at the mRNA level in PK5L1940 and BRAF cell-derived allograft tumors obtained from Rag1 -/- mice injected with Th2 cells in relation to untreated Rag1 -/- mice are increased. Representative images of immunohistochemistry staining showing that MBP ( b ), MPO ( c ) and NOS2 ( d ... View More

Product Image Gallery

Product Details

MA1-24990

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

View 6 publications 6 publications

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent

Immunocytochemistry (ICC/IF)

Assay-dependent

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

Product Specifications

Species Reactivity

Bovine, Human, Many, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rat / IgG2b

Class

Monoclonal

Type

Antibody

Clone

Immunogen

Bovine myelin basic protein.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. not determined

Storage buffer

tissue culture supernatant

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_794984

Product Specific Information

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils.

British journal of cancer

Jacenik D,Karagiannidis I,Beswick EJ

MA1-24990 was used in Immunohistochemistry-immunofluorescence to demonstrate the significance of Th2 cells, eosinophils and IL-5 in the inhibition of gastrointestinal tumor growth, and pointed toward tumor microenvironment reprogramming as a Th2 cell-mediated anti-tumorigenic mechanism of action.

Sun Jan 01 00:00:00 UTC 2023

Th2 cells inhibit growth of colon and pancreas cancers by promoting anti-tumorigenic responses from macrophages and eosinophils.

British journal of cancer

Jacenik D,Karagiannidis I,Beswick EJ

Sun Jan 01 00:00:00 UTC 2023

Overexpression of OLIG2 and MYT1L Transcription Factors Enhance the Differentiation Potential of Human Mesenchymal Stem Cells into Oligodendrocytes.

Current issues in molecular biology

Fahim I,Ishaque A,Ramzan F,Shamsuddin SABA,Ali A,Salim A,Khan I

MA1-24990 was used in Immunocytochemistry to differentiate hUC-MSCs into oligodendrocyte-like cells, which is greatly facilitated by the oligo induction medium.

Sun May 07 00:00:00 UTC 2023

Clinical and histomolecular endometrial tumor characterization of patients at-risk for Lynch syndrome in South of Brazil.

Familial cancer

Cossio SL,Koehler-Santos P,Pessini SA,Mónego H,Edelweiss MI,Meurer L,Errami A,Coffa J,Bock H,Saraiva-Pereira ML,Ashton-Prolla P,Prolla JC

MA1-24990 was used in immunohistochemistry - paraffin section to measure the frequency of mismatch repair deficiencies in women diagnosed with endometrial cancer who are at-risk for Lynch syndrome

Tue Jun 01 00:00:00 UTC 2010

Clinical implications of microsatellite instability and MLH1 gene inactivation in sporadic insulinomas.

The Journal of clinical endocrinology and metabolism

Mei M,Deng D,Liu TH,Sang XT,Lu X,Xiang HD,Zhou J,Wu H,Yang Y,Chen J,Lu CM,Chen YJ

MA1-24990 was used in immunohistochemistry - paraffin section to discuss biomarkers for insulinomas

Tue Sep 01 00:00:00 UTC 2009

Impact of microsatellite instability (MSI) on survival in high grade endometrial carcinoma.

Gynecologic oncology

Arabi H,Guan H,Kumar S,Cote M,Bandyopadhyay S,Bryant C,Shah J,Abdul-Karim FW,Munkarah AR,Ali-Fehmi R

MA1-24990 was used in immunohistochemistry - paraffin section to correlate microstellite instability and other clinicopathologic markers with survival of patients with high grade endometrial carcinoma

Fri May 01 00:00:00 UTC 2009

Expression of hMLH1 and hMSH2 proteins in pleomorphic adenoma of minor salivary glands: relationship with clinical and histologic findings.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics

Tobón-Arroyave SI,Flórez-Moreno GA,Jaramillo-Cárdenas JF,Arango-Uribe JD,Isaza-Guzmán DM,Rendón-Henao J

MA1-24990 was used in immunohistochemistry - paraffin section to assess the relationship between clinicopathological features and expression of hMLH1 and hMSH2 proteins in pleomorphic adenoma of minor salivary glands

Sat Aug 01 00:00:00 UTC 2009

Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer.

Oncology reports

Bendardaf R,Lamlum H,Ristamäki R,Syrjänen K,Pyrhönen S

MA1-24990 was used in immunohistochemistry - paraffin section to determine the expression of Bcl-2, hMLH1, and hMSH2 in patients with advanced colorectal cancer and correlate their expression with therapeutic response and disease outcome

Sat Nov 01 00:00:00 UTC 2008

Sebaceous carcinoma of the eyelids: thirty cases from Japan.

Pathology international

Izumi M,Mukai K,Nagai T,Matsubayashi J,Iwaya K,Chiu CS,Goto H

MA1-24990 was used in immunohistochemistry - paraffin section to characterize thirty cases of sebaceous carcinoma of the eyelids

Fri Aug 01 00:00:00 UTC 2008

Bioinformatics

Protein Aliases: 20 kDa microtubule-stabilizing protein; golli mbp; Golli-Mbp; myelin basic protein; Golli-Mbp; myelin basic protein; myelin basic protein S; MBP; MBP S; MGC99675; microtubule-stabilizing protein; Myelin A1 protein; Myelin basic protein; myelin basic protein Golli-mbp; myelin basic protein S; myelin deficient; Myelin membrane encephalitogenic protein; shiverer

View more View less

Gene Aliases: BOS_22097; C76307; golli-mbp; Hmbpr; MBP; Mbps; mld; R75289; Shi

View more View less

UniProt ID: (Human) P02686, (Rat) P02688, (Mouse) P04370

View more View less

Entrez Gene ID: (Human) 4155, (Bovine) 618684, (Rat) 24547, (Mouse) 17196

View more View less

Function(s)

protease binding protein binding structural constituent of myelin sheath

Process(es)

immune response chemical synaptic transmission central nervous system development aging axon ensheathment response to toxic substance substantia nigra development response to progesterone response to tumor necrosis factor myelination response to mercury ion negative regulation of axonogenesis membrane organization response to fatty acid

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

MBP Monoclonal Antibody (14)

MBP Antibody (MA1-24990) in IHC

Product Details

MA1-24990

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

ELISA (ELISA)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!