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Invitrogen
MC3R Polyclonal Antibody
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Product Details
PA5-33924
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 18 amino acid peptide from C-Terminus of human MC3 Receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551292
Product Specific Information
Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Horse, Pig (94%); Bat, Rabbit, Platypus (89%); Opossum, Turkey, Chicken, Xenopus, Trout (83%).
Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.
Target Information
This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MC3 receptor; MC3-R; Melanocortin receptor 3; obesity quantitative trait locus
Gene Aliases: BMIQ9; MC3; MC3-R; MC3R; OB20; OQTL
UniProt ID: (Human) P41968
Entrez Gene ID: (Human) 4159
regulation of heart rate
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
regulation of blood pressure
positive regulation of cAMP biosynthetic process
circadian regulation of gene expression
homoiothermy
locomotor rhythm
sodium ion homeostasis
regulation of feeding behavior
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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