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Invitrogen
MCHR1 Recombinant Rabbit Monoclonal Antibody (12H4L9)
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FIGURE: 1 / 3
MCHR1 Antibody (702618) in ICC/IF
For immunofluorescence analysis, HEK-293 cells were stably transfected with human MCHR1. After 24hr of transfection the cells were fixed and permeabilized for detection of MCHR1 using Anti-MCHR1 Recombinant Rabbit Monoclonal Antibody (Product # 702618, 1 µg/mL, 1:500 dilution) and labeled with Goat anti-Rabbit IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate. Panel a) shows representative cells that were stained for detection of membrane localization of the MCHR1 on the transfected cells. The images were captured at 40... View More
Product Details
702618
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
12H4L9
Immunogen
Peptide corresponding to human MCHR1 [aa401-aa422]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2734816
Product Specific Information
This antibody is predicted to react with Monkey, Mouse, Rabbit.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
MCHR1 is a member of the G protein-coupled receptor family 1. It is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: G protein-coupled receptor 24; G-protein coupled receptor 24; GPCR24; MCH 1 receptor; MCH receptor 1; MCH-1R; MCH-R1; MCH1; MCH1R; MCHR; MCHR-1; Melanin-concentrating hormone receptor 1; SLC-1; Somatostatin receptor-like protein
Gene Aliases: GPR24; MCH-1R; MCH1R; MCHR1; SLC-1; SLC1
UniProt ID: (Human) Q99705, (Rat) P97639
Entrez Gene ID: (Human) 2847, (Rat) 83567
cell surface receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
positive regulation of calcium ion transport
generation of precursor metabolites and energy
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
feeding behavior
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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