Proteintech

MCM6 Polyclonal Antibody

MCM6 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 19

MCM6 Antibody (13347-2-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HeLa cells using 13347-2-AP (MCM6 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

MCM6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MCM6 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13347-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MCM6 Fusion Protein Ag4180 (471-821 aa encoded by BC032374)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VAIHEAMEQ QTISITKAGV KATLNARTSI LAAANPISGH YDRSKSLKQN INLSAPIMSR FDLFFILVDE CNEVTDYAIA RRIVDLHSRI EESIDRVYSL DDIRRYLLFA RQFKPKISKE SEDFIVEQYK HLRQRDGSGV TKSSWRITVR QLESMIRLSE AMARMHCCDE VQPKHVKEAF RLLNKSIIRV ETPDVNLDQE EEIQMEVDEG AGGINGHADS PAPVNGINGY NEDINQESAP KASLRLGFSE YCRISNLIVL HLRKVEEEED ESALKRSELV NWYLKEIESE IDSEEELINK KRIIEKVIHR LTHYDHVLIE LTQAGLKGST EGSESYEEDP YLVVNPNYLL ED (471-821 aa encoded by BC032374)

Target Information

MCM6 may be involved in the control of a single round of DNA replication during S phase. It binds to chromatin during G1 and detaches from it during S phase as if it licenses the chromatin to replicate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

MCMBP promotes the assembly of the MCM2-7 hetero-hexamer to ensure robust DNA replication in human cells.

eLife

Saito Y,Santosa V,Ishiguro KI,Kanemaki MT

Tue Apr 19 00:00:00 UTC 2022

Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma.

Journal of hematology & oncology

Tong Y,Sun M,Chen L,Wang Y,Li Y,Li L,Zhang X,Cai Y,Qie J,Pang Y,Xu Z,Zhao J,Zhang X,Liu Y,Tian S,Qin Z,Feng J,Zhang F,Zhu J,Xu Y,Lou W,Ji Y,Zhao J,He F,Hou Y,Ding C

Fri Nov 25 00:00:00 UTC 2022

Cadherin-16 inhibits thyroid carcinoma cell proliferation and invasion.

Oncology letters

Yang X,Li Y,Liu G,Zha W,Liu Y

Sun May 01 00:00:00 UTC 2022

ACTL6A deficiency induces apoptosis through impairing DNA replication and inhibiting the ATR-Chk1 signaling in glioblastoma cells.

Biochemical and biophysical research communications

Hu X,Pei D,Ci M,Zhang G,Li B,Wang J,Shen Y,Zhai X,Liang P,Cui H

Sat Apr 09 00:00:00 UTC 2022

Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.

Nature cancer

Shen M,Wei Y,Kim H,Wan L,Jiang YZ,Hang X,Raba M,Remiszewski S,Rowicki M,Wu CG,Wu S,Zhang L,Lu X,Yuan M,Smith HA,Zheng A,Bertino J,Jin JF,Xing Y,Shao ZM,Kang Y

Sat Jan 01 00:00:00 UTC 2022

The influence of phenolic environmental estrogen on the transcriptome of uterine leiomyoma cells: A whole transcriptome profiling-based analysis.

Ecotoxicology and environmental safety

Li Z,Yin H,Shen Y,Ren M,Xu X

Mon Mar 15 00:00:00 UTC 2021

Plasma membrane calcium ATPase 1 regulates human umbilical vein endothelial cell angiogenesis and viability.

Journal of molecular and cellular cardiology

Njegic A,Swiderska A,Marris C,Armesilla AL,Cartwright EJ

Thu Jul 01 00:00:00 UTC 2021

Minichromosome maintenance 6 complex component identified by bioinformatics analysis and experimental validation in esophageal squamous cell carcinoma.

Oncology reports

Li X,Ren Z,Xiong C,Geng J,Li Y,Liu C,Ren C,Liu H

Tue Sep 01 00:00:00 UTC 2020

METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway.

Frontiers in oncology

Yang DD,Chen ZH,Yu K,Lu JH,Wu QN,Wang Y,Ju HQ,Xu RH,Liu ZX,Zeng ZL

Mon Sep 28 00:00:00 UTC 2020

CtIP promotes G2/M arrest in etoposide-treated HCT116 cells in a p53-independent manner.

Journal of cellular physiology

Chen H,Shan J,Chen D,Wang R,Qi W,Wang H,Ke Y,Liu W,Zeng X

Mon Jul 01 00:00:00 UTC 2019

CtIP promotes G2/M arrest in etoposide-treated HCT116 cells in a p53-independent manner.

Journal of cellular physiology

Chen H,Shan J,Chen D,Wang R,Qi W,Wang H,Ke Y,Liu W,Zeng X

Mon Jul 01 00:00:00 UTC 2019

Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.

Biomaterials

Song H,Guo T,Zhao Z,Wei Y,Luo H,Weng W,Zhang R,Zhong M,Chen C,Su J,Shen W

Sat Sep 01 00:00:00 UTC 2018

Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.

Biomaterials

Song H,Guo T,Zhao Z,Wei Y,Luo H,Weng W,Zhang R,Zhong M,Chen C,Su J,Shen W

Sat Sep 01 00:00:00 UTC 2018

Overexpression of MCM6 predicts poor survival in patients with glioma.

Human pathology

Cai HQ,Cheng ZJ,Zhang HP,Wang PF,Zhang Y,Hao JJ,Wang MR,Wan JH

Wed Aug 01 00:00:00 UTC 2018

Overexpression of MCM6 predicts poor survival in patients with glioma.

Human pathology

Cai HQ,Cheng ZJ,Zhang HP,Wang PF,Zhang Y,Hao JJ,Wang MR,Wan JH

Wed Aug 01 00:00:00 UTC 2018

MCM6 promotes metastasis of hepatocellular carcinoma via MEK/ERK pathway and serves as a novel serum biomarker for early recurrence.

Journal of experimental & clinical cancer research : CR