Proteintech

MCRS1 Polyclonal Antibody

FIGURE: 1 / 8

MCRS1 Antibody (11362-1-AP) in WB

Mouse uterus tissue were subjected to SDS PAGE followed by western blot with 11362-1-AP (MCRS1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Image Gallery

Product Details

11362-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunocytochemistry (ICC/IF)

Assay-dependent

View 2 publications 2 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

ChIP assay (ChIP)

Assay-dependent

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MCRS1 Fusion Protein Ag1904 (1-462 aa encoded by BC011794)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDKDSQGLL DSSLMASGTA SRSEDEESLA GQKRASSQAL GTIPKRRSSS RFIKRKKFDD ELVESSLAKS STRAKGASGV EPGRCSGSEP SSSEKKKVSK APSTPVPPSP APAPGLTKRV KKSKQPLQVT KDLGRWKPAD DLLLINAVLQ TNDLTSVHLG VKFSCRFTLR EVQERWYALL YDPVISKLAC QAMRQLHPEA IAAIQSKALF SKAEEQLLSK VGSTSQPTLE TFQDLLHRHP DAFYLARTAK ALQAHWQLMK QYYLLEDQTV QPLPKGDQVL NFSDAEDLID DSKLKDMRDE VLEHELMVAD RRQKREIRQL EQELHKWQVL VDSITGMSSP DFDNQTLAVL RGRMVRYLMR SREITLGRAT KDNQIDVDLS LEGPAWKISR KQGVIKLKNN GDFFIANEGR RPIYIDGRPV LCGSKWRLSN NSVVEIASLR FVFLINQDLI ALIRAEAAKI TPQ (1-462 aa encoded by BC011794)

Target Information

Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis.

EMBO reports

Ju JQ,Pan ZN,Zhang KH,Ji YM,Liu JC,Sun SC

Thu May 04 00:00:00 UTC 2023

Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis.

EMBO reports

Ju JQ,Pan ZN,Zhang KH,Ji YM,Liu JC,Sun SC

Thu May 04 00:00:00 UTC 2023

Mcrs1 regulates G2/M transition and spindle assembly during mouse oocyte meiosis.

EMBO reports

Ju JQ,Pan ZN,Zhang KH,Ji YM,Liu JC,Sun SC

Thu May 04 00:00:00 UTC 2023

Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment.

Molecular biology of the cell

Yang H,Zhang F,Huang CJ,Liao J,Han Y,Hao P,Chu Y,Lu X,Li W,Yu H,Kang J

Mon Apr 15 00:00:00 UTC 2019

Identification of Two Distinct Classes of the Human INO80 Complex Genome-Wide.

G3 (Bethesda, Md.)

Runge JS,Raab JR,Magnuson T

Wed Mar 28 00:00:00 UTC 2018

Identification of Two Distinct Classes of the Human INO80 Complex Genome-Wide.

G3 (Bethesda, Md.)

Runge JS,Raab JR,Magnuson T

Wed Mar 28 00:00:00 UTC 2018

MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.

Cell

Chatterjee A,Seyfferth J,Lucci J,Gilsbach R,Preissl S,Böttinger L,Mårtensson CU,Panhale A,Stehle T,Kretz O,Sahyoun AH,Avilov S,Eimer S,Hein L,Pfanner N,Becker T,Akhtar A

Thu Oct 20 00:00:00 UTC 2016

MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria.

Cell

Chatterjee A,Seyfferth J,Lucci J,Gilsbach R,Preissl S,Böttinger L,Mårtensson CU,Panhale A,Stehle T,Kretz O,Sahyoun AH,Avilov S,Eimer S,Hein L,Pfanner N,Becker T,Akhtar A

Thu Oct 20 00:00:00 UTC 2016

MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.

Scientific reports

Lee SH,Lee MS,Choi TI,Hong H,Seo JY,Kim CH,Kim J

Mon Jun 06 00:00:00 UTC 2016

MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.

Scientific reports

Lee SH,Lee MS,Choi TI,Hong H,Seo JY,Kim CH,Kim J

Mon Jun 06 00:00:00 UTC 2016

MOF-associated complexes ensure stem cell identity and Xist repression.

eLife

Chelmicki T,Dündar F,Turley MJ,Khanam T,Aktas T,Ramírez F,Gendrel AV,Wright PR,Videm P,Backofen R,Heard E,Manke T,Akhtar A

Mon May 19 00:00:00 UTC 2014

MOF-associated complexes ensure stem cell identity and Xist repression.

eLife

Chelmicki T,Dündar F,Turley MJ,Khanam T,Aktas T,Ramírez F,Gendrel AV,Wright PR,Videm P,Backofen R,Heard E,Manke T,Akhtar A

Mon May 19 00:00:00 UTC 2014

Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.

The Journal of biological chemistry

Chen L,Cai Y,Jin J,Florens L,Swanson SK,Washburn MP,Conaway JW,Conaway RC

Fri Apr 01 00:00:00 UTC 2011

Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling.

The Journal of biological chemistry

Chen L,Cai Y,Jin J,Florens L,Swanson SK,Washburn MP,Conaway JW,Conaway RC

Fri Apr 01 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: 58 kDa microspherule protein; cell cycle-regulated factor (78 kDa); Cell cycle-regulated factor p78; INO80 complex subunit J; INO80 complex subunit Q; MCRS2; Microspherule protein 1; nucleolar protein

View more View less

Gene Aliases: C78274; ICP22BP; INO80Q; MCRS1; MCRS2; MSP58; P78

View more View less

UniProt ID: (Human) Q96EZ8, (Mouse) Q99L90

View more View less

Entrez Gene ID: (Human) 10445, (Rat) 300222, (Mouse) 51812

View more View less

Function(s)

G-quadruplex RNA binding protein binding poly(U) RNA binding poly(G) binding histone acetyltransferase activity (H4-K5 specific) histone acetyltransferase activity (H4-K8 specific) histone acetyltransferase activity (H4-K16 specific) molecular_function

Process(es)

biological_process histone H4-K5 acetylation histone H4-K8 acetylation histone H4-K16 acetylation DNA repair DNA recombination transcription, DNA-templated regulation of transcription, DNA-templated cellular response to DNA damage stimulus chromatin modification cellular protein modification process positive regulation of protein localization to nucleolus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

MCRS1 Polyclonal Antibody

MCRS1 Antibody (11362-1-AP) in WB

Product Details

11362-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!