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Product Details
60215-1-IG
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2H10E10
Immunogen
MCRS1 Fusion Protein Ag1904 (1-462 aa encoded by BC011794)
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDKDSQGLL DSSLMASGTA SRSEDEESLA GQKRASSQAL GTIPKRRSSS RFIKRKKFDD ELVESSLAKS STRAKGASGV EPGRCSGSEP SSSEKKKVSK APSTPVPPSP APAPGLTKRV KKSKQPLQVT KDLGRWKPAD DLLLINAVLQ TNDLTSVHLG VKFSCRFTLR EVQERWYALL YDPVISKLAC QAMRQLHPEA IAAIQSKALF SKAEEQLLSK VGSTSQPTLE TFQDLLHRHP DAFYLARTAK ALQAHWQLMK QYYLLEDQTV QPLPKGDQVL NFSDAEDLID DSKLKDMRDE VLEHELMVAD RRQKREIRQL EQELHKWQVL VDSITGMSSP DFDNQTLAVL RGRMVRYLMR SREITLGRAT KDNQIDVDLS LEGPAWKISR KQGVIKLKNN GDFFIANEGR RPIYIDGRPV LCGSKWRLSN NSVVEIASLR FVFLINQDLI ALIRAEAAKI TPQ (1-462 aa encoded by BC011794)
Target Information
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 58 kDa microspherule protein; cell cycle-regulated factor (78 kDa); Cell cycle-regulated factor p78; INO80 complex subunit J; INO80 complex subunit Q; MCRS2; Microspherule protein 1; nucleolar protein
Gene Aliases: C78274; ICP22BP; INO80Q; MCRS1; MCRS2; MSP58; P78
UniProt ID: (Human) Q96EZ8, (Mouse) Q99L90
Entrez Gene ID: (Human) 10445, (Rat) 300222, (Mouse) 51812
biological_process
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K16 acetylation
DNA repair
DNA recombination
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
chromatin modification
cellular protein modification process
positive regulation of protein localization to nucleolus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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