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Invitrogen
MDFI Polyclonal Antibody
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Product Details
PA5-142482
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-SKSTTSQIPLQAQED (aa 148-162).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933130
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
MDFI is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. MDFI an also interfere with the DNA-binding activity of Myod family members and plays an important role in trophoblast and chondrogenic differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: inhibitor of MyoD family a; MyoD family inhibitor; Myogenic repressor I-mf
Gene Aliases: I-MF; I-mfa; MDFI
UniProt ID: (Human) Q99750
Entrez Gene ID: (Human) 4188
negative regulation of transcription from RNA polymerase II promoter
activation of JUN kinase activity
embryo development
dorsal/ventral axis specification
negative regulation of Wnt signaling pathway
cytoplasmic sequestering of transcription factor
negative regulation of DNA binding
negative regulation of transcription, DNA-templated
embryonic skeletal system morphogenesis
trophoblast giant cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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