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Product Details
PA5-63339
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MED11. Recombinant protein control fragment (Product #RP-93365).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2643841
Product Specific Information
Immunogen sequence: YSLANERLRA LEDIEREIGA ILQNAGTVIL ELSKEKTNER LLDRQAAAFT ASVQHVEAEL SAQIRYLTQV ATGQPHEGSS YSSRKDCQMA LKRVDYARLK LSDVARTCEQ MLE
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 98%.
Target Information
In mammalian cells, transcription is regulated in part by high molecular weight co-activating complexes that mediate signals between transcriptional activators and RNA polymerase II (Pol II). The mediator complex is one such multiprotein structure that functions as a bridge between regulatory proteins and Pol II, thereby regulating Pol II-dependent transcription. Med11 (mediator complex subunit 11) is a 117 amino acid nuclear protein and component of the mediator complex. The gene encoding Med11 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, and is associated with predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mediator complex subunit 11; Mediator of RNA polymerase II transcription subunit 11; mediator of RNA polymerase II transcription, subunit 11 homolog
Gene Aliases: HSPC296; MED11
UniProt ID: (Human) Q9P086
Entrez Gene ID: (Human) 400569
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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