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Invitrogen
MED25 Monoclonal Antibody (7F1)
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Product Details
MA5-24469
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
7F1
Immunogen
MED9 (NP_060489.1, 1 a.a. ~ 146 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2633441
Product Specific Information
Peptide Sequence: MASAGVAAGR QAEDVLPPTS DQPLPDTKPL PPPQPPPVPA PQPQQSPAPR PQSPARAREE ENYSFLPLVH NIIKCMDKDS PEVHQDLNAL KSKFQEMRKL ISTMPGIHLS PEQQQQQLQS LREQVRTKNE LLQKYKSLCM FEIPKE
Target Information
This gene encodes a component of the transcriptional coactivator complex termed the Mediator complex. This complex is required for transcription of most RNA polymerase II-dependent genes. The encoded protein plays a role in chromatin modification and in preinitiation complex assembly. Mutations in this gene are associated with Charcot-Marie-Tooth disease type 2B2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activator interaction domain-containing protein 1; Activator-recruited cofactor 92 kDa component; ARC/mediator transcriptional coactivator subunit; ARC92; DKFZp434K0512; Mediator complex subunit 25; Mediator of RNA polymerase II transcription subunit 25; mediator of RNA polymerase II transcription, subunit 25 homolog; MGC70671; p78; prostate-derived protein 78 kDa
Gene Aliases: ACID1; ARC92; BVSYS; CMT2B2; MED25; P78; PTOV2; TCBAP0758
UniProt ID: (Human) Q71SY5
Entrez Gene ID: (Human) 81857
negative regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
positive regulation of chromatin binding
positive regulation of transcription from RNA polymerase II promoter
negative regulation of fibroblast proliferation
positive regulation of cell cycle arrest
positive regulation of mediator complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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