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Proteintech
MED28 Polyclonal Antibody
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Product Details
16262-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MED28 Fusion Protein Ag9327 (1-178 aa encoded by BC011936)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAAPLGGMF SGQPPGPPQA PPGLPGQASL LQAAPGAPRP SSSTLVDELE SSFEACFASL VSQDYVNGTD QEEIRTGVDQ CIQKFLDIAR QTECFFLQKR LQLSVQKPEQ VIKEDVSELR NELQRKDALV QKHLTKLRHW QQVLEDINVQ HKKPADIPQG SLAYLEQASA NIPAPLKPT (1-178 aa encoded by BC011936 )
Target Information
The mediator complex is a multi-protein transcriptional co-activator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factor. One of the proteins in this complex is MED28, also known as Magicin. MED28 is expressed in many cell lines and tissues. It has been shown that a down-regulation of MED28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell differentiation and conversely its over-expression represses expression of SMC genes. MED28 can also form a ternary complex with Grb2 and Merlin, the neurofibromatosis 2 tumor suppressor protein, indicating that MED28 may play a role in Merlin's tumor suppressive activity. MED28 has also been recently identified as an HIV dependency factor (HDF), suggesting that MED28 may be an important drug target in HIV treatment. At least two isoforms of MED28 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: endothelial-derived; endothelial-derived gene 1; Endothelial-derived protein 1; Magicin; Mediator complex subunit 28; Mediator of RNA polymerase II transcription subunit 28; mediator of RNA polymerase II transcription, subunit 28 homolog; Merlin and Grb2-interacting cytoskeletal protein; Tumor angiogenesis marker EG-1
Gene Aliases: 1500003D12Rik; AI451633; AU045690; EG1; FKSG20; magicin; MED28; RGD1305875
UniProt ID: (Human) Q9H204, (Rat) P68943, (Mouse) Q920D3
Entrez Gene ID: (Human) 80306, (Rat) 305391, (Mouse) 66999
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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