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          • Primary Antibodies ›
          • MEF2A/MEF2C Antibodies

          Invitrogen

          MEF2A/MEF2C Recombinant Rabbit Monoclonal Antibody (JE63-26)

          View all (2) MEF2A/MEF2C antibodies

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          Datasheet
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          Cite MEF2A/MEF2C Recombinant Rabbit Monoclonal Antibody (JE63-26)

          • Antibody Testing Data (7)
          MEF2A/MEF2C Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          MEF2A/MEF2C Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 7

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          MEF2A/MEF2C Antibody (MA5-44778) in IHC (P)

          Immunohistochemistry analysis of MEF2A + MEF2C in paraffin-embedded human striated muscle tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 2 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with MEF2A + MEF2C Monoclonal antibody (Product # MA5-44778) using a dilution of ... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          MEF2A/MEF2C Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MEF2A/MEF2C Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MEF2A/MEF2C Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MEF2A/MEF2C Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MEF2A/MEF2C Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MEF2A/MEF2C Antibody in Western Blot (WB)
          MEF2A/MEF2C Antibody in Flow Cytometry (Flow)

          Product Details

          MA5-44778

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:400
          -

          Flow Cytometry (Flow)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Expression System

          HEK293 cells

          Class

          Recombinant Monoclonal

          Type

          Antibody

          Clone

          JE63-26

          Immunogen

          Recombinant protein within human MEF2C aa 250-473/473.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          TBS, pH 7.4, with 0.05% BSA, 40% glycerol

          Contains

          0.05% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2931235

          Target Information

          MEF2A is found in many muscle specific-genes mediating cellular functions in skeletal and cardiac muscle. MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: ADCAD1; C5DELq14.3; DEL5q14.3; MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A); MADS box transcription enhancer factor 2, polypeptide C; mef2; Myocyte enhancer factor 2C; Myocyte-specific enhancer factor 2A; Myocyte-specific enhancer factor 2C; NEDHSIL; RSRFC4; RSRFC9; Serum response factor-like protein 1

          View more View less

          Gene Aliases: 5430401D19Rik; 9930028G15Rik; A430079H05Rik; ADCAD1; AV011172; C5DELq14.3; DEL5q14.3; MEF2; MEF2A; MEF2C; RGD1563119; RSRFC4; RSRFC9

          View more View less

          UniProt ID: (Human) Q02078, (Human) Q06413, (Mouse) Q60929, (Rat) Q2MJT0, (Rat) A0A096MJY4, (Mouse) Q8CFN5

          View more View less

          Entrez Gene ID: (Human) 4205, (Human) 4208, (Mouse) 17258, (Rat) 309957, (Rat) 499497, (Mouse) 17260

          View more View less

          Function(s)
          RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding RNA polymerase II transcription coactivator activity chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding protein kinase binding activating transcription factor binding histone acetyltransferase binding histone deacetylase binding sequence-specific DNA binding SMAD binding protein heterodimerization activity RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter sequence-specific core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding AT DNA binding miRNA binding transcription regulatory region DNA binding HMG box domain binding DNA binding protein dimerization activity core promoter proximal region sequence-specific DNA binding
          Process(es)
          mitochondrial genome maintenance negative regulation of transcription from RNA polymerase II promoter MAPK cascade transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter apoptotic process multicellular organism development nervous system development cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter mitochondrion distribution dendrite morphogenesis ventricular cardiac myofibril assembly cardiac conduction ERK5 cascade cellular response to calcium ion heart development cellular response to glucose stimulus blood vessel development osteoblast differentiation neuron migration B cell homeostasis heart looping endochondral ossification blood vessel remodeling chondrocyte differentiation germinal center formation regulation of germinal center formation primary heart field specification secondary heart field specification outflow tract morphogenesis sinoatrial valve morphogenesis cardiac ventricle formation humoral immune response muscle organ development skeletal muscle tissue development muscle cell fate determination learning or memory response to virus positive regulation of gene expression negative regulation of gene expression positive regulation of alkaline phosphatase activity neural crest cell differentiation cardiac muscle hypertrophy in response to stress myotube differentiation neuron differentiation platelet formation monocyte differentiation negative regulation of ossification melanocyte differentiation positive regulation of bone mineralization positive regulation of B cell proliferation cellular response to drug skeletal muscle cell differentiation cellular response to trichostatin A B cell proliferation regulation of neuron apoptotic process negative regulation of neuron apoptotic process regulation of megakaryocyte differentiation positive regulation of myoblast differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation regulation of neurotransmitter secretion regulation of synaptic plasticity positive regulation of skeletal muscle tissue development neuron development cell morphogenesis involved in neuron differentiation embryonic viscerocranium morphogenesis negative regulation of epithelial cell proliferation B cell receptor signaling pathway smooth muscle cell differentiation positive regulation of muscle cell differentiation regulation of synapse assembly regulation of synaptic transmission, glutamatergic ventricular cardiac muscle cell differentiation palate development regulation of synaptic activity positive regulation of cardiac muscle cell proliferation excitatory postsynaptic potential regulation of sarcomere organization cartilage morphogenesis regulation of dendritic spine development renal tubule morphogenesis cellular response to lipopolysaccharide cellular response to parathyroid hormone stimulus cellular response to fluid shear stress cellular response to transforming growth factor beta stimulus positive regulation of cell proliferation in bone marrow glomerulus morphogenesis nephron tubule epithelial cell differentiation positive regulation of protein homodimerization activity positive regulation of macrophage apoptotic process regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity positive regulation of cardiac muscle cell differentiation positive regulation of behavioral fear response epithelial cell proliferation involved in renal tubule morphogenesis positive regulation of skeletal muscle cell differentiation response to ischemia positive regulation of cardiac muscle hypertrophy dentate gyrus development response to nutrient levels response to vitamin E positive regulation of MAP kinase activity cell fate commitment embryonic skeletal system morphogenesis cardiac muscle cell differentiation transdifferentiation cellular response to retinoic acid cellular response to growth factor stimulus cellular response to organic cyclic compound
          It has to be done as per old AB suggested Products section.
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