Proteintech

MEFV Polyclonal Antibody

FIGURE: 1 / 1

MEFV Antibody (24280-1-AP) in WB

Human plasma tissue were subjected to SDS PAGE followed by western blot with 24280-1-AP ( MEFV Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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Product Details

24280-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

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Immunocytochemistry (ICC/IF)

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Flow Cytometry (Flow)

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Immunoprecipitation (IP)

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Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MEFV Fusion Protein Ag18000 (1-350 aa encoded by BC101511)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.49 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAKTPSDHL LSTLEELVPY DFEKFKFKLQ NTSVQKEHSR IPRSQIQRAR PVKMATLLVT YYGEEYAVQL TLQVLRAINQ RLLAEELHRA AIQEYSTQEN GTDDSAASSS LGENKPRSLK TPDHPEGNEG NGPRPYGGGA ASLRCSQPEA GRGLSRKPLS KRREKASEGL DAQGKPRTRS PALPGGRSPG PCRALEGGQA EVQLRRNASS AGRLQGLAGG APGQKECRPF EVYLPSGKMR PRSLEVTIST GEKAPANPEI LLTLEEKTAA NLDSATEPRA RPTPDGGASA DLKEGPGNPE HSVTGRPPDT AASPRCHAQE GDPVDGTCVR DSCSFPEAVS GHPQASGSRS P (1-350 aa encoded by BC101511)

Target Information

This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes.

Autophagy

Hegdekar N,Sarkar C,Bustos S,Ritzel RM,Hanscom M,Ravishankar P,Philkana D,Wu J,Loane DJ,Lipinski MM

Sat Jul 01 00:00:00 UTC 2023

Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes.

Autophagy

Hegdekar N,Sarkar C,Bustos S,Ritzel RM,Hanscom M,Ravishankar P,Philkana D,Wu J,Loane DJ,Lipinski MM

Sat Jul 01 00:00:00 UTC 2023

Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever.

PLoS biology

Mangan MSJ,Gorki F,Krause K,Heinz A,Pankow A,Ebert T,Jahn D,Hiller K,Hornung V,Maurer M,Schmidt FI,Gerhard R,Latz E

Tue Nov 01 00:00:00 UTC 2022

Function and mechanism of pyrin and IL-10 in the regulation of the inflammasome in pulmonary vascular endothelial cells following hemorrhagic shock.

Experimental and therapeutic medicine

Jin X,Yao Y,Lu X,Xu P,Xia Y,Zhu S

Sun Sep 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: HGNC:6998; Marenostrin; MGC126560; MGC126586; Pyrin

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Gene Aliases: FMF; MEF; MEFV; TRIM20

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UniProt ID: (Human) O15553

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Entrez Gene ID: (Human) 4210

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Function(s)

actin binding protein binding zinc ion binding

Process(es)

inflammatory response positive regulation of autophagy negative regulation of interleukin-1 beta production negative regulation of interleukin-12 production response to interferon-gamma negative regulation of inflammatory response negative regulation of macrophage inflammatory protein 1 alpha production negative regulation of cytokine production involved in inflammatory response negative regulation of NLRP3 inflammasome complex assembly positive regulation of cysteine-type endopeptidase activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MEFV Polyclonal Antibody

MEFV Antibody (24280-1-AP) in WB

Product Details

24280-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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