Proteintech

MEK1 Polyclonal Antibody

MEK1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 4

MEK1 Antibody (51080-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human endometrial cancer tissue slide using 51080-1-AP ( MEK1-Specific antibody at dilution of 1:50 (under 40x lens).

Product Image Gallery

Product Details

51080-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is specific to MEK1.

Target Information

MAP2K1 (MEK1) kinase is a dual-specificity protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. Mek1 is activated by phosphorylation of serine 218 and 222 residues by Raf1. It is known to be involved in the signaling during stress activate response, apoptosis and proliferative induction by cytokines. Mutations in the gene can lead to cardiofaciocutaneous syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Elevated PGT promotes proliferation and inhibits cell apoptosis in preeclampsia by Erk signaling pathway.

Molecular and cellular probes

Pang H,Lei D,Huang J,Guo Y,Fan C

Wed Feb 01 00:00:00 UTC 2023

5'-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I.

Frontiers of medicine

Wu C,Liu D,Zhang L,Wang J,Ding Y,Sun Z,Wang W

Thu Jun 01 00:00:00 UTC 2023

4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.

Cancer cell international

Li W,Huang BS,Xiong YY,Yang LJ,Wu LX

Tue Jan 18 00:00:00 UTC 2022

MiR-155-5p suppresses SOX1 to promote proliferation of cholangiocarcinoma via RAF/MEK/ERK pathway.

Cancer cell international

Wang D,Xiong F,Wu G,Liu W,Wang B,Chen Y

Tue Dec 07 00:00:00 UTC 2021

Effects of dietary icariin supplementation on the ovary development-related transcriptome of Chinese mitten crab (Eriocheir sinensis).

Comparative biochemistry and physiology. Part D, Genomics & proteomics

Zheng X,Zhang L,Jiang W,Abasubong KP,Zhang C,Zhang D,Li X,Jiang G,Chi C,Liu W

Mon Mar 01 00:00:00 UTC 2021

FANCI Cooperates with IMPDH2 to Promote Lung Adenocarcinoma Tumor Growth via a MEK/ERK/MMPs Pathway.

OncoTargets and therapy

Zheng P,Li L

Tue Apr 12 00:00:00 UTC 2022

Proteomic Analysis of eIF5B Silencing-Modulated Proteostasis.

PloS one

Jiang X,Jiang X,Feng Y,Xu R,Wang Q,Deng H

Tue Jul 11 00:00:00 UTC 2017

Proteomic Analysis of eIF5B Silencing-Modulated Proteostasis.

PloS one

Jiang X,Jiang X,Feng Y,Xu R,Wang Q,Deng H

Tue Jul 11 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 1; EC 2.7.12.2; ERK activator kinase 1; kinase MEK1; MAP kinase kinase 1; MAPK/ERK kinase 1; MAPKK 1; MEK 1; MEK2; MKK (Thr292); MKK (Thr386); MKK2; MP2K1; PRKMK2; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)

View more View less

Gene Aliases: CFC3; MAP2K1; MAPKK1; MEK1; MKK1; PRKMK1

View more View less

UniProt ID: (Human) Q02750

View more View less

Entrez Gene ID: (Human) 5604

View more View less

Function(s)

protein kinase activity protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity receptor signaling protein tyrosine phosphatase activity protein binding ATP binding protein C-terminus binding protein kinase binding protein serine/threonine kinase activator activity protein N-terminus binding

Process(es)

MAPK cascade activation of MAPK activity movement of cell or subcellular component chemotaxis cell cycle arrest signal transduction heart development negative regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression peptidyl-tyrosine phosphorylation cerebellar cortex formation neuron differentiation keratinocyte differentiation thyroid gland development regulation of stress-activated MAPK cascade proteolysis in other organism positive regulation of transcription, DNA-templated thymus development regulation of axon regeneration cell motility positive regulation of axonogenesis Bergmann glial cell differentiation face development trachea formation epithelial cell proliferation involved in lung morphogenesis placenta blood vessel development labyrinthine layer development ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance cellular senescence mitophagy in response to mitochondrial depolarization positive regulation of production of miRNAs involved in gene silencing by miRNA regulation of early endosome to late endosome transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

MEK1 Polyclonal Antibody

MEK1 Antibody (51080-1-AP) in IHC (P)

Product Details

51080-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!