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MEK4 Polyclonal Antibody

MEK4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MEK4 Antibody (17340-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 17340-1-AP) (MAP2K4 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

17340-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MEK4 Fusion Protein Ag11376 (50-399 aa encoded by BC036032)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: NPPFKSTAR FTLNPNPTGV QNPHIERLRT HSIESSGKLK ISPEQHWDFT AEDLKDLGEI GRGAYGSVNK MVHKPSGQIM AVKRIRSTVD EKEQKQLLMD LDVVMRSSDC PYIVQFYGAL FREGDCWICM ELMSTSFDKF YKYVYSVLDD VIPEEILGKI TLATVKALNH LKENLKIIHR DIKPSNILLD RSGNIKLCDF GISGQLVDSI AKTRDAGCRP YMAPERIDPS ASRQGYDVRS DVWSLGITLY ELATGRFPYP KWNSVFDQLT QVVKGDPPQL SNSEEREFSP SFINFVNLCL TKDESKRPKY KELLKHPFIL MYEERAVEVA CYVCKILDQM PATPSSPMYV D (50-399 aa encoded by BC036032)

Target Information

MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. MAP2K4 mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MAP2K4 is important for carcinogenesis; a loss-off-function mutation in MAP2K4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MAP2K4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Gu L,He X,Zhang Y,Li S,Tang J,Ma R,Yang X,Huang H,Peng Y,Xie Y,Peng Z,Meng J,Hu G,Tao L,Liu X,Yang H

Tue Aug 01 00:00:00 UTC 2023

A new prognosis prediction model combining TNM stage with MAP2K4 and JNK in postoperative pancreatic cancer patients.

Pathology, research and practice

Liu XD,Zhang ZW,Wu HW,Liang ZY

Fri Jan 01 00:00:00 UTC 2021

A new prognosis prediction model combining TNM stage with MAP2K4 and JNK in postoperative pancreatic cancer patients.

Pathology, research and practice

Liu XD,Zhang ZW,Wu HW,Liang ZY

Fri Jan 01 00:00:00 UTC 2021

Regulation of CREB Phosphorylation in Nucleus Accumbens after Relief Conditioning.

Cells

Soleimanpour E,Bergado Acosta JR,Landgraf P,Mayer D,Dankert E,Dieterich DC,Fendt M

Tue Jan 26 00:00:00 UTC 2021

NR4A1 counteracts JNK activation incurred by ER stress or ROS in pancreatic β-cells for protection.

Journal of cellular and molecular medicine

Pu ZQ,Liu D,Lobo Mouguegue HPP,Jin CW,Sadiq E,Qin DD,Yu TF,Zong C,Chen JC,Zhao RX,Lin JY,Cheng J,Yu X,Li X,Zhang YC,Liu YT,Guan QB,Wang XD

Tue Dec 01 00:00:00 UTC 2020

Dual effects of JNK activation in blood-milk barrier damage induced by zinc oxide nanoparticles.

Journal of hazardous materials

Wu J,Lai X,Cui G,Chen Q,Liu J,Kang Y,Zhang Y,Feng X,Hu C,Shao L

Sun Nov 15 00:00:00 UTC 2020

Huai Qi Huang-induced Apoptosis via Down-regulating PRKCH and Inhibiting RAF/MEK/ERK Pathway in Ph⁺ Leukemia Cells.

Current medical science

Xu WF,Wang ZJ,Li K,Shen YQ,Lu K,Lv XY,Wen YX,Jin RM

Wed Apr 01 00:00:00 UTC 2020

Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway.

EBioMedicine

Liu Y,Jiang Q,Liu X,Lin X,Tang Z,Liu C,Zhou J,Zhao M,Li X,Cheng Z,Li L,Xie Y,Liu Z,Fang W

Tue Oct 01 00:00:00 UTC 2019

EBioMedicine

Liu Y,Jiang Q,Liu X,Lin X,Tang Z,Liu C,Zhou J,Zhao M,Li X,Cheng Z,Li L,Xie Y,Liu Z,Fang W

Tue Oct 01 00:00:00 UTC 2019

Androgen-induced miR-27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression.

The international journal of biochemistry & cell biology

Wan X,Huang W,Yang S,Zhang Y,Zhang P,Kong Z,Li T,Wu H,Jing F,Li Y

Sat Oct 01 00:00:00 UTC 2016

Androgen-induced miR-27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression.

The international journal of biochemistry & cell biology

Wan X,Huang W,Yang S,Zhang Y,Zhang P,Kong Z,Li T,Wu H,Jing F,Li Y

Sat Oct 01 00:00:00 UTC 2016

LPS induced miR-181a promotes pancreatic cancer cell migration via targeting PTEN and MAP2K4.

Digestive diseases and sciences

Liu J,Xu D,Wang Q,Zheng D,Jiang X,Xu L

Tue Jul 01 00:00:00 UTC 2014

LPS induced miR-181a promotes pancreatic cancer cell migration via targeting PTEN and MAP2K4.

Digestive diseases and sciences

Liu J,Xu D,Wang Q,Zheng D,Jiang X,Xu L

Tue Jul 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: C-JUN N-terminal kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 4; JNK kinase 1; JNK-activated kinase 1; JNK-activating kinase 1; JNKK; JNKK 1; MAP kinase kinase 4; MAPK/ERK kinase 4; MAPKK 4; MEK 4; mitogen activated protein kinase kinase 4, variant 1; SAPK kinase 1; SAPK/ERK kinase 1; SAPK/Erk/kinase 1; SEK1; Stress-activated protein kinase kinase 1

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Gene Aliases: JNKK; JNKK1; MAP2K4; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1

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UniProt ID: (Human) P45985, (Mouse) P47809

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Entrez Gene ID: (Human) 6416, (Mouse) 26398

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Function(s)

protein kinase activity receptor signaling protein serine/threonine kinase activity protein tyrosine kinase activity protein binding ATP binding nucleotide binding protein serine/threonine kinase activity MAP kinase kinase activity JUN kinase kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups mitogen-activated protein kinase kinase kinase binding

Process(es)

MAPK cascade positive regulation of protein phosphorylation protein phosphorylation apoptotic process JNK cascade activation of JUN kinase activity phosphorylation positive regulation of apoptotic process positive regulation of neuron apoptotic process positive regulation of DNA replication positive regulation of nitric-oxide synthase biosynthetic process cell growth involved in cardiac muscle cell development signal transduction response to wounding peptidyl-tyrosine phosphorylation proteolysis in other organism Fc-epsilon receptor signaling pathway cellular response to mechanical stimulus negative regulation of motor neuron apoptotic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MEK4 Polyclonal Antibody

MEK4 Antibody (17340-1-AP) in IHC (P)

Product Details

17340-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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