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Invitrogen
MEKK1 Polyclonal Antibody
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Product Details
PA5-79629
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human MEKK1 (1418-1432aa PEVLRGQQYGRSCDV).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746744
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: MCF-7 whole cell. IHC: Human Intestinal Cancer Tissue.
Target Information
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK1 can phosphorylate and activate MAPKK 1 and MAPKK 2 (MEK1/MEK2) which leads to phosphorylation of MAP kinases. It is also a highly efficient activator of the JNK cascade. The protein contains a putative 1 RING-type zinc finger and 1 SWIM-type zinc finger.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MAP/ERK kinase kinase 1; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1; mitogen activated protein kinase kinase kinase 1; Mitogen-activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Gene Aliases: MAP3K1; MAPKKK1; MEKK; MEKK 1; MEKK1; SRXY6
UniProt ID: (Human) Q13233, (Rat) Q62925
Entrez Gene ID: (Human) 4214, (Mouse) 26401, (Rat) 116667
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
zinc ion binding
protein kinase binding
nucleotide binding
JUN kinase kinase kinase activity
ubiquitin-protein transferase activity
JUN kinase binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
mitogen-activated protein kinase kinase binding
sphingolipid binding
metal ion binding
mitogen-activated protein kinase binding
JUN kinase kinase activity
MAPK cascade
activation of MAPKK activity
MyD88-dependent toll-like receptor signaling pathway
protein phosphorylation
apoptotic process
Fc-epsilon receptor signaling pathway
cellular response to mechanical stimulus
epithelial cell morphogenesis
transforming growth factor beta receptor signaling pathway
JNK cascade
activation of JNKK activity
activation of JUN kinase activity
regulation of mitotic cell cycle
apoptotic mitochondrial changes
phosphorylation
protein ubiquitination
regulation of cell migration
positive regulation of actin filament polymerization
wound healing
regulation of apoptotic process
camera-type eye development
eyelid development in camera-type eye
protein polyubiquitination
response to osmotic stress
peptidyl-serine phosphorylation
negative regulation of actin filament bundle assembly
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of JUN kinase activity
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
positive regulation of viral transcription
protein oligomerization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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