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Product Details
BS-9673R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human MEL18, amino acids 170-210.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA-binding protein Mel-18; Melanoma nuclear protein 18; MGC10545; Polycomb group RING finger protein 2; RING finger protein 110; Zfp-144; Zinc finger protein 144
Gene Aliases: MEL-18; MEL18; PCGF2; RNF110; Zfp144; ZNF144
UniProt ID: (Human) P35227, (Mouse) P23798
Entrez Gene ID: (Human) 7703, (Rat) 287662, (Mouse) 22658
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
anterior/posterior pattern specification
protein ubiquitination
histone acetylation
embryonic skeletal system morphogenesis
cellular response to hydrogen peroxide
negative regulation of apoptotic signaling pathway
transcription, DNA-templated
protein sumoylation
regulation of transcription, DNA-templated
embryonic skeletal system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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