Proteintech

MEN1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

15159-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:50
-

Immunoprecipitation (IP)

0.5-4.0 µg
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MEN1 Fusion Protein Ag7253 (226-575 aa encoded by BC002544)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.44 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QKLLWLLYD LGHLERYPMA LGNLADLEEL EPTPGRPDPL TLYHKGIASA KTYYRDEHIY PYMYLAGYHC RNRNVREALQ AWADTATVIQ DYNYCREDEE IYKEFFEVAN DVIPNLLKEA ASLLEAGEER PGEQSQGTQS QGSALQDPEC FAHLLRFYDG ICKWEEGSPT PVLHVGWATF LVQSLGRFEG QVRQKVRIVS REAEAAEAEE PWGEEAREGR RRGPRRESKP EEPPPPKKPA LDKGLGTGQG AVSGPPRKPP GTVAGTARGP EGGSTAQVPA PAASPPPEGP VLTFQSEKMK GMKELLVATK INSSAIKLQL TAQSQVQMKK QKVSTPSDYT LSFLKRQRKG L (226-575 aa encoded by BC002544)

Target Information

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Menin; multiple endocrine neoplasia I

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Gene Aliases: MEAI; MEN1; SCG2

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UniProt ID: (Human) O00255

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Entrez Gene ID: (Human) 4221

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Function(s)
four-way junction DNA binding Y-form DNA binding chromatin binding double-stranded DNA binding protein binding histone-lysine N-methyltransferase activity protein binding, bridging transcription regulatory region DNA binding protein N-terminus binding R-SMAD binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade mitotic cell cycle negative regulation of protein phosphorylation osteoblast development type B pancreatic cell differentiation DNA repair transcription, DNA-templated cellular response to DNA damage stimulus brain development negative regulation of cell proliferation response to UV response to gamma radiation negative regulation of cell-substrate adhesion positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of protein binding regulation of activin receptor signaling pathway histone lysine methylation negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of osteoblast differentiation negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade decidualization negative regulation of epithelial cell proliferation negative regulation of telomerase activity regulation of type B pancreatic cell proliferation cellular response to glucose stimulus cellular response to peptide hormone stimulus response to transforming growth factor beta negative regulation of cell cycle G1/S phase transition beta-catenin-TCF complex assembly
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