Rockland

MEN1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

200-901-MJ8

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
-

Immunohistochemistry (IHC)

1:500
-

ELISA (ELISA)

1:10,000-1:50,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Chicken / IgY

Class

Polyclonal

Type

Antibody

Immunogen

Anti-Menin1 antibody was prepared from eggs of chickens laid after repeated immunizations with a synthetic peptide corresponding to a C-Terminal portion of human MEN1 conjugated to Keyhole Limpet Hemocyanin (KLH).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

selective precipitation

Storage buffer

PBS, pH 7

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

This affinity purified antibody is directed against human Menin1. This product is an IgY fraction antibody purified from monospecific chicken egg yolks by a multi-step process which includes selective precipitation and salt fractionation followed by extensive dialysis against the buffer stated above. Blast analysis the immunogen sequence shows 100% identity withhuman, mouse, rat, bovine, canine, and is highly conserved.

Target Information

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Menin; multiple endocrine neoplasia I

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Gene Aliases: MEAI; MEN1; SCG2

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UniProt ID: (Human) O00255

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Entrez Gene ID: (Human) 4221

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Function(s)
four-way junction DNA binding Y-form DNA binding chromatin binding double-stranded DNA binding protein binding histone-lysine N-methyltransferase activity protein binding, bridging transcription regulatory region DNA binding protein N-terminus binding R-SMAD binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade mitotic cell cycle negative regulation of protein phosphorylation osteoblast development type B pancreatic cell differentiation DNA repair transcription, DNA-templated cellular response to DNA damage stimulus brain development negative regulation of cell proliferation response to UV response to gamma radiation negative regulation of cell-substrate adhesion positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of protein binding regulation of activin receptor signaling pathway histone lysine methylation negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of osteoblast differentiation negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade decidualization negative regulation of epithelial cell proliferation negative regulation of telomerase activity regulation of type B pancreatic cell proliferation cellular response to glucose stimulus cellular response to peptide hormone stimulus response to transforming growth factor beta negative regulation of cell cycle G1/S phase transition beta-catenin-TCF complex assembly
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