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MEP1B Antibody (MA5-23991) in IHC (P)
Immunohistochemical analysis of MEP1B in immersion fixed paraffin-embedded sections of human intestine. Samples were incubated in MEP1B monoclonal antibody (Product # MA5-23991) using a dilution of 1 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic. Tissue was stained using the Anti-Rat HRP-DAB ... View More
Product Details
MA5-23991
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rat
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
289731
Immunogen
Human embryonic kidney cell line HEK293-derived recombinant human Meprin beta Subunit/MEP1B Thr23-Ser293
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2607663
Product Specific Information
This antibody detects the pro form of human or mouse Meprin beta Subunit/MEP1B in Western blots. This antibody does not react with the mature form.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.4.24.63; Endopeptidase-2; meprin A; Meprin A subunit beta; meprin A, beta; Meprin B; meprin beta; N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta
Gene Aliases: Mep-1b; MEP1B
UniProt ID: (Human) Q16820, (Mouse) Q61847
Entrez Gene ID: (Human) 4225, (Mouse) 17288
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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