Invitrogen

MESP1 Polyclonal Antibody

View all (6) MESP1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-87675

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 149-268 of human MESP1 (NP_0611401)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.54 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804339

Product Specific Information

Immunogen sequence: RRCRQRGDAG SPRGCPLCPD DCPAQMQTRT QAEGQGQGRG LGLVSAVRAG ASWGSPPACP GARAAPEPRD PPALFAEAAC PEGQAMEPSP PSPLLPGDVL ALLETWMPLS PLEWLPEEPK; Positive Samples: A-549, HeLa, THP-1, Mouse heart, Rat heart; Cellular Location: Nucleus

Target Information

Mesp1 (mesoderm posterior 1) is a basic helix-loop-helix-type transcription factor, which along with its related proteins, has an essential role in both segmentation and rostro-caudal patterning of somites in the anterior pre-somitic mesoderm. Mesp1 is expressed in many of the precursors of the cardiovascular system and is known to play a role in the process of cardiac morphogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bHLHc5; Class C basic helix-loop-helix protein 5; mesoderm posterior 1 homolog; mesoderm posterior basic helix-loop-helix transcription factor 1; Mesoderm posterior protein 1; MGC10676

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Gene Aliases: BHLHC5; MESP1

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UniProt ID: (Human) Q9BRJ9, (Mouse) P97309

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Entrez Gene ID: (Human) 55897, (Rat) 308766, (Mouse) 17292

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding enhancer binding transcription regulatory region DNA binding protein dimerization activity DNA binding
Process(es)
heart looping secondary heart field specification embryonic heart tube morphogenesis cardiac atrium formation cardiac ventricle formation sinus venosus morphogenesis growth involved in heart morphogenesis cardioblast anterior-lateral migration transcription from RNA polymerase II promoter Notch signaling pathway gastrulation mesodermal cell migration neurogenesis signal transduction involved in regulation of gene expression positive regulation of Notch signaling pathway involved in heart induction negative regulation of mesodermal cell fate specification negative regulation of endodermal cell fate specification endothelial cell differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter lateral mesoderm development positive regulation of striated muscle cell differentiation cardiac muscle cell differentiation cardiac cell fate determination sinoatrial node cell differentiation cardiac vascular smooth muscle cell differentiation cardioblast migration to the midline involved in heart field formation positive regulation of hepatocyte differentiation positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway heart morphogenesis cardioblast migration transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development
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