Proteintech

MFN1 Monoclonal Antibody (3F11C11)

MFN1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

MFN1 Antibody (66776-1-IG) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using (Product # 66776-1-IG) (MFN1 antibody) at dilution of 1:100 and CoraLite488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

MFN1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

66776-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:10,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:500-1:2,000

Immunocytochemistry (ICC/IF)

1:100

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

3F11C11

Immunogen

MFN1 Fusion Protein Ag4890 (27-351 aa encoded by BC040557)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EFVTEGSHF VEATYKNPEL DRIATEDDLV EMQGYKDKLS IIGEVLSRRH MKVAFFGRTS SGKSSVINAM LWDKVLPSGI GHITNCFLSV EGTDGDKAYL MTEGSDEKKS VKTVNQLAHA LHMDKDLKAG CLVRVFWPKA KCALLRDDLV LVDSPGTDVT TELDSWIDKF CLDADVFVLV ANSESTLMNT EKHFFHKVNE RLSKPNIFIL NNRWDASASE PEYMEDVRRQ HMERCLHFLV EELKVVNALE AQNRIFFVSA KEVLSARKQK AQGMPESGVA LAEGFHARLQ EFQNFEQIFE ECISQSAVKT KFEQHTIRAK QILATV (27-351 aa encoded by BC040557)

Target Information

Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

miR-494-5p mediates the antioxidant activity of EPA by targeting the mitochondrial elongation factor 1 gene MIEF1 in HepG2 cells.

The Journal of nutritional biochemistry

Lin Y,Wu X,Lin L,Mei Y,Zhou J,Chen C,Li J,Wu D,Liu J,Li G

Mon May 01 00:00:00 UTC 2023

Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer's Disease.

Biomolecules

Fihurka O,Wang Y,Hong Y,Lin X,Shen N,Yang H,Brown B,Mommer M,Zieneldien T,Li Y,Kim J,Li M,Cai J,Zhou Q,Cao C

Wed Jan 25 00:00:00 UTC 2023

Zinc deficiency compromises the maturational competence of porcine oocyte by inducing mitophagy and apoptosis.

Ecotoxicology and environmental safety

Lai XL,Xiong WJ,Li LS,Lan MF,Zhang JX,Zhou YT,Niu D,Duan X

Wed Mar 01 00:00:00 UTC 2023

Cardiolipin and OPA1 Team up for Methamphetamine-Induced Locomotor Activity by Promoting Neuronal Mitochondrial Fusion in the Nucleus Accumbens of Mice.

ACS chemical neuroscience

Wang L,Wei Q,Xu R,Chen Y,Li S,Bu Q,Zhao Y,Li H,Zhao Y,Jiang L,Chen Y,Dai Y,Zhao Y,Cen X

Wed May 03 00:00:00 UTC 2023

Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.

Journal of molecular histology

Wang F,Han J,Wang X,Liu Y,Zhang Z

Sat Oct 01 00:00:00 UTC 2022

Xiangsha Liujunzi Decoction improves gastrointestinal motility in functional dyspepsia with spleen deficiency syndrome by restoring mitochondrial quality control homeostasis.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Zhang J,Wang X,Wang F,Tang X

Sat Oct 01 00:00:00 UTC 2022

Nujiangexanthone A Inhibits Cervical Cancer Cell Proliferation by Promoting Mitophagy.

Molecules (Basel, Switzerland)

Feng J,Mansouripour A,Xi Z,Zhang L,Xu G,Zhou H,Xu H

Wed May 12 00:00:00 UTC 2021

BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects.

Nature communications

Choi GE,Lee HJ,Chae CW,Cho JH,Jung YH,Kim JS,Kim SY,Lim JR,Han HJ

Wed Jan 20 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: DKFZp762F247; EC 3.6.5; FLJ20693; Fzo homolog; MGC41806; mitochondrial transmembrane GTPase Fzo-1; mitochondrial transmembrane GTPase FZO-2; Mitochondrial transmembrane GTPase FZO1B; Mitofusin-1; putative transmembrane GTPase; Transmembrane GTPase MFN1

View more View less

Gene Aliases: 2310002F04Rik; 6330416C07Rik; D3Ertd265e; Fzo1b; hfzo1; hfzo2; HR2; MFN1; mKIAA4032

View more View less

UniProt ID: (Human) Q8IWA4, (Rat) Q8R4Z9, (Mouse) Q811U4

View more View less

Entrez Gene ID: (Human) 55669, (Rat) 192647, (Mouse) 67414

View more View less

Function(s)

GTPase activity protein binding GTP binding nucleotide binding hydrolase activity

Process(es)

mitochondrial fusion metabolic process multicellular organism development macroautophagy

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

MFN1 Monoclonal Antibody (3F11C11)

MFN1 Antibody (66776-1-IG) in ICC/IF

Product Details

66776-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!