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          • Primary Antibodies ›
          • MFN2 Antibodies

          Proteintech

          MFN2 Polyclonal Antibody

          245 References
          View all (38) MFN2 antibodies

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          Cite MFN2 Polyclonal Antibody

          • Antibody Testing Data (15)
          MFN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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          MFN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 15

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          MFN2 Antibody (12186-1-AP) in IHC (P)

          Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using (Product # 12186-1-AP) (MFN2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          MFN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MFN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MFN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MFN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MFN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MFN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MFN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MFN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MFN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          MFN2 Antibody in Western Blot (WB)
          MFN2 Antibody in Western Blot (WB)
          MFN2 Antibody in Western Blot (WB)
          MFN2 Antibody in Western Blot (WB)
          MFN2 Antibody in Immunoprecipitation (IP)
          MFN2 Antibody in Immunoprecipitation (IP)

          Product Details

          12186-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:1,000
          View 206 publications 206 publications

          Immunohistochemistry (IHC)

          -
          View 13 publications 13 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:500
          -

          Immunocytochemistry (ICC/IF)

          -
          View 14 publications 14 publications

          Immunoprecipitation (IP)

          0.5-4.0 µg
          View 6 publications 6 publications

          Miscellaneous PubMed (MISC)

          -
          View 2 publications 2 publications

          Not applicable (N/A)

          -
          View 4 publications 4 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          MFN2 Fusion Protein Ag2845 (2-353 aa encoded by BC017061)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.2 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: SLLFSRCNS IVTVKKNKRH MAEVNASPLK HFVTAKKKIN GIFEQLGAYI QESATFLEDT YRNAELDPVT TEEQVLDVKG YLSKVRGISE VLARRHMKVA FFGRTSNGKS TVINAMLWDK VLPSGIGHTT NCFLRVEGTD GHEAFLLTEG SEEKRSAKTV NQLAHALHQD KQLHAGSLVS VMWPNSKCPL LKDDLVLMDS PGIDVTTELD SWIDKFCLDA DVFVLVANSE STLMQTEKHF FHKVSERLSR PNIFILNNRW DASASEPEYM EEVRRQHMER CTSFLVDELG VVDRSQAGDR IFFVSAKEVL NARIQKAQGM PEGGGALAEG FQVRMFEFQN FERRFEECIS QSA (2-353 aa encoded by BC017061)

          Target Information

          This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: CPRP 1; HSG protein; hyperplasia suppressor; hypertension related protein 1; hypertension-related protein; Hypertension-related protein 1; MFN 2; Mitochondrial assembly regulatory factor; mitochondrial transmembrane GTPase FZO1A; Mitofusin-2; Mitofusin2; Transmembrane GTPase MFN2

          View more View less

          Gene Aliases: CMT2A; CMT2A2; CPRP1; D630023P19Rik; Fzo; HMSN6A; HSG; KIAA0214; MARF; MFN2

          View more View less

          UniProt ID: (Human) O95140, (Mouse) Q80U63

          View more View less

          Entrez Gene ID: (Human) 9927, (Mouse) 170731, (Rat) 64476

          View more View less

          Function(s)
          GTPase activity protein binding GTP binding ubiquitin protein ligase binding nucleotide binding hydrolase activity GTPase binding
          Process(es)
          blastocyst formation protein targeting to mitochondrion autophagy apoptotic process response to unfolded protein mitochondrial membrane organization multicellular organism development mitochondrial fusion protein localization to pre-autophagosomal structure negative regulation of Ras protein signal transduction camera-type eye morphogenesis negative regulation of smooth muscle cell proliferation mitochondrion localization cell cycle arrest blood coagulation macroautophagy parkin-mediated mitophagy in response to mitochondrial depolarization metabolic process negative regulation of cell proliferation
          It has to be done as per old AB suggested Products section.
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