Proteintech

MFN2 Monoclonal Antibody (5F3B3)

MFN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MFN2 Antibody (67487-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 67487-1-Ig (MFN2 antibody) at dilution of 1:2000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

67487-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:20,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:2,000

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

5F3B3

Immunogen

MFN2 Fusion Protein Ag29873

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1000 µg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mitofusin2 Ameliorated Endoplasmic Reticulum Stress and Mitochondrial Reactive Oxygen Species Through Maintaining Mitochondria-Associated Endoplasmic Reticulum Membrane Integrity in Cisplatin-Induced Acute Kidney Injury.

Antioxidants & redox signaling

Liu YT,Zhang H,Duan SB,Wang JW,Chen H,Zhan M,Zhang W,Li AM,Liu Y,Yang Y,Yang S

Mon Jan 01 00:00:00 UTC 2024

Antioxidants & redox signaling

Liu YT,Zhang H,Duan SB,Wang JW,Chen H,Zhan M,Zhang W,Li AM,Liu Y,Yang Y,Yang S

Mon Jan 01 00:00:00 UTC 2024

Antioxidants & redox signaling

Liu YT,Zhang H,Duan SB,Wang JW,Chen H,Zhan M,Zhang W,Li AM,Liu Y,Yang Y,Yang S

Mon Jan 01 00:00:00 UTC 2024

Antioxidants & redox signaling

Liu YT,Zhang H,Duan SB,Wang JW,Chen H,Zhan M,Zhang W,Li AM,Liu Y,Yang Y,Yang S

Mon Jan 01 00:00:00 UTC 2024

Myricetin improves pathological changes in 3×Tg-AD mice by regulating the mitochondria-NLRP3 inflammasome-microglia channel by targeting P38 MAPK signaling pathway.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Liu P,Zhou Y,Shi J,Wang F,Yang X,Zheng X,Wang Y,He Y,Xie X,Pang X

Sat Jul 01 00:00:00 UTC 2023

Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer's Disease.

Biomolecules

Fihurka O,Wang Y,Hong Y,Lin X,Shen N,Yang H,Brown B,Mommer M,Zieneldien T,Li Y,Kim J,Li M,Cai J,Zhou Q,Cao C

Wed Jan 25 00:00:00 UTC 2023

Cardiolipin and OPA1 Team up for Methamphetamine-Induced Locomotor Activity by Promoting Neuronal Mitochondrial Fusion in the Nucleus Accumbens of Mice.

ACS chemical neuroscience

Wang L,Wei Q,Xu R,Chen Y,Li S,Bu Q,Zhao Y,Li H,Zhao Y,Jiang L,Chen Y,Dai Y,Zhao Y,Cen X

Wed May 03 00:00:00 UTC 2023

Loganin alleviated cognitive impairment in 3×Tg-AD mice through promoting mitophagy mediated by optineurin.

Journal of ethnopharmacology

Zhou Y,Luo D,Shi J,Yang X,Xu W,Gao W,Guo Y,Zhao Q,Xie X,He Y,Du G,Pang X

Thu Aug 10 00:00:00 UTC 2023

Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1.

Autophagy

Liu Y,Zhang H,Liu Y,Zhang S,Su P,Wang L,Li Y,Liang Y,Wang X,Zhao W,Chen B,Luo D,Zhang N,Yang Q

Fri Sep 01 00:00:00 UTC 2023

Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats.

Nutrients

Zhong Y,Li Z,Jin R,Yao Y,He S,Lei M,Wang X,Shi C,Gao L,Peng X

Thu Nov 24 00:00:00 UTC 2022

Diosgenin Ameliorated Type II Diabetes-Associated Nonalcoholic Fatty Liver Disease through Inhibiting De Novo Lipogenesis and Improving Fatty Acid Oxidation and Mitochondrial Function in Rats.

Nutrients

Zhong Y,Li Z,Jin R,Yao Y,He S,Lei M,Wang X,Shi C,Gao L,Peng X

Thu Nov 24 00:00:00 UTC 2022

Roles of HIF-1α/BNIP3 mediated mitophagy in mitochondrial dysfunction of letrozole-induced PCOS rats.

Journal of molecular histology

Wang F,Han J,Wang X,Liu Y,Zhang Z

Sat Oct 01 00:00:00 UTC 2022

Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart.

The journal of physiological sciences : JPS

Chen Z,Zhou Z,Peng X,Sun C,Yang D,Li C,Zhu R,Zhang P,Zheng L,Tang C

Mon Nov 08 00:00:00 UTC 2021

Nujiangexanthone A Inhibits Cervical Cancer Cell Proliferation by Promoting Mitophagy.

Molecules (Basel, Switzerland)

Feng J,Mansouripour A,Xi Z,Zhang L,Xu G,Zhou H,Xu H

Wed May 12 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: CPRP 1; HSG protein; hyperplasia suppressor; hypertension related protein 1; hypertension-related protein; Hypertension-related protein 1; MFN 2; Mitochondrial assembly regulatory factor; mitochondrial transmembrane GTPase FZO1A; Mitofusin-2; Mitofusin2; Transmembrane GTPase MFN2

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Gene Aliases: CMT2A; CMT2A2; CPRP1; D630023P19Rik; Fzo; HMSN6A; HSG; KIAA0214; MARF; MFN2

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UniProt ID: (Human) O95140, (Mouse) Q80U63

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Entrez Gene ID: (Human) 9927, (Mouse) 170731, (Rat) 64476

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Function(s)

GTPase activity protein binding GTP binding ubiquitin protein ligase binding nucleotide binding hydrolase activity GTPase binding

Process(es)

blastocyst formation protein targeting to mitochondrion autophagy apoptotic process response to unfolded protein mitochondrial membrane organization multicellular organism development mitochondrial fusion protein localization to pre-autophagosomal structure negative regulation of Ras protein signal transduction camera-type eye morphogenesis negative regulation of smooth muscle cell proliferation mitochondrion localization cell cycle arrest blood coagulation macroautophagy parkin-mediated mitophagy in response to mitochondrial depolarization metabolic process negative regulation of cell proliferation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MFN2 Monoclonal Antibody (5F3B3)

MFN2 Antibody (67487-1-IG) in IHC (P)

Product Details

67487-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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