Invitrogen

MFSD2A Polyclonal Antibody

MFSD2A Antibody in Immunocytochemistry (ICC/IF)

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MFSD2A Antibody (PA5-21049) in ICC/IF

Immunofluorescence of MFSD2A in Rat Lung cells with MFSD2A Polyclonal Antibody (Product # PA5-21049) at 20 µg/mL.

MFSD2A Antibody in Immunohistochemistry (IHC)

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Product Details

PA5-21049

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

View 3 publications 3 publications

Immunohistochemistry (IHC)

5 µg/mL

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

20 µg/mL

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

An 18 amino acid peptide near the carboxy terminus of human MFSD2A.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_11152332

Product Specific Information

A suggested positive control is rat lung tissue lysate.

PA5-21049 can be used with blocking peptide PEP-1163.

Target Information

Multidrug transporters, such as MFSD2A, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2A is a novel lung cancer tumor suppressor gene that regulates cell cycle progression and matrix attachment and has recently been described as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. The activation of the betaAR signaling pathway plays a major role in the induction of MFSD2A expression during adaptive thermogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood-brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis.

Fluids and barriers of the CNS

Zhang Y,Wang L,Pan Q,Yang X,Cao Y,Yan J,Wang Y,Tao Y,Fan R,Sun X,Li L

PA5-21049 was used in Western Blot, Immunohistochemistry (Frozen) to investigate the effect of CYM-5442 on vesicle transcytosis, we downregulated and upregulated Mfsd2a expression using a specific AAV prior to evaluation of the TBI model.

Mon Jul 11 00:00:00 UTC 2022

Selective sphingosine-1-phosphate receptor 1 modulator attenuates blood-brain barrier disruption following traumatic brain injury by inhibiting vesicular transcytosis.

Fluids and barriers of the CNS

Zhang Y,Wang L,Pan Q,Yang X,Cao Y,Yan J,Wang Y,Tao Y,Fan R,Sun X,Li L

Mon Jul 11 00:00:00 UTC 2022

Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain.

Nature communications

Zhao L,Li Z,Vong JSL,Chen X,Lai HM,Yan LYC,Huang J,Sy SKH,Tian X,Huang Y,Chan HYE,So HC,Ng WL,Tang Y,Lin WJ,Mok VCT,Ko H

PA5-21049 was used in Western Blotting to reveal transcriptomic alterations underlying brain endothelial cells (EC) ageing that are complex yet pharmacologically reversible.

Fri Sep 04 00:00:00 UTC 2020

Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain.

Nature communications

Zhao L,Li Z,Vong JSL,Chen X,Lai HM,Yan LYC,Huang J,Sy SKH,Tian X,Huang Y,Chan HYE,So HC,Ng WL,Tang Y,Lin WJ,Mok VCT,Ko H

PA5-21049 was used in Western Blotting to reveal transcriptomic alterations underlying brain endothelial cells (EC) ageing that are complex yet pharmacologically reversible.

Fri Sep 04 00:00:00 UTC 2020

MiR-155 deletion reduces ischemia-induced paralysis in an aortic aneurysm repair mouse model: Utility of immunohistochemistry and histopathology in understanding etiology of spinal cord paralysis.

Annals of diagnostic pathology

Awad H,Bratasz A,Nuovo G,Burry R,Meng X,Kelani H,Brown M,Ramadan ME,Williams J,Bouhliqah L,Popovich PG,Guan Z,Mcallister C,Corcoran SE,Kaspar B,Michele Basso D,Otero JJ,Kirsch C,Davis IC,Croce CM,Michaille JJ,Tili E

PA5-21049 was used in Immunohistochemistry to study the histopathology of thoraco-abdominal aortic aneurysm and determine the role of miR-155 ablation in the reduction of spinal cord damage.

Mon Oct 01 00:00:00 UTC 2018

Mfsd2a and Glut1 Brain Nutrient Transporters Expression Increase with 32-Week Low and High Lard Compared with Fish-Oil Dietary Treatment in C57Bl/6 Mice.

Current developments in nutrition

Sandoval KE,Wooten JS,Harris MP,Schaller ML,Umbaugh DS,Witt KA

Published figure using MFSD2A polyclonal antibody (Product # PA5-21049) in Western Blot

Mon Oct 01 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: HsMFSD2A; major facilitator superfamily domain containing 2; Major facilitator superfamily domain-containing protein 2A; Mfsd2a; NLS1; sodium-dependent LPC symporter 1; Sodium-dependent lysophosphatidylcholine symporter 1; zgc:101615

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Gene Aliases: 1700018O18Rik; HMFN0656; MCPH15; MFSD2; MFSD2A; NLS1; PP9177; RGD1310174; UNQ300/PRO341

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UniProt ID: (Human) Q8NA29, (Mouse) Q9DA75

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Entrez Gene ID: (Human) 84879, (Rat) 298504, (Mouse) 76574

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Function(s)

phospholipid transporter activity symporter activity

Process(es)

fatty acid transport phospholipid transport transcytosis transmembrane transport establishment of blood-brain barrier lipid transport across blood brain barrier transport lipid transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MFSD2A Polyclonal Antibody

MFSD2A Antibody (PA5-21049) in ICC/IF

Product Details

PA5-21049

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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