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Immunogen sequence: EVSTSLKVY QGHTLEKTYM GEDFFWAITP IAGDYILFKF DKPVNVESYL FHSGNQEHPG DILLNTTVEV LPFKSEGLEI SKETKDKRLE DGYFRIGKFE NGVAEGMVDP SL (395-505 aa encoded by BC127107)
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2.4.1.145; Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A; alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase; GlcNAc-T IVa; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A; N-acetylglucosaminyltransferase IVa; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa; UDP-GlcNAc:a-1,3-D-mannoside b-1,4-acetylglucosaminyltransferase IV; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa; UDP-N-acetylglucosamine:alpha1,3-d-mannoside beta1,4-N-acetylglucosaminyltransferase
Gene Aliases: GnT-4a; GNT-IV; GNT-IVA; MGAT4A
UniProt ID: (Human) Q9UM21
Entrez Gene ID: (Human) 11320
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