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Invitrogen
MHC Class I Monoclonal Antibody (IVA26), Alexa Fluor™ 488
FIGURE: 1 / 2
MHC Class I Antibody (MA5-44137) in Flow
Separation of bovine lymphocytes stained using anti-bovine MHC Class I (IVA26) Alexa Fluor® 488 Monoclonal antibody (Product # MA5-44137), concentration in sample 1 µg/mL (red-filled) from bovine lymphocytes stained using mouse IgG1 isotype control (MOPC-21) Alexa Fluor® 488 antibody (concentration in sample 1 µg/mL, black-dashed) in flow cytometry analysis (surface staining) of bovine peripheral whole blood.
Product Details
MA5-44137
Product Specifications
Species Reactivity
Avian,
Bovine,
Human,
Mouse,
Sheep,
Pig,
Rabbit
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
IVA26
Immunogen
bovine lymphocytes
Conjugate
Excitation/Emission Max
499/520 nm
View spectra
Form
Liquid
Concentration
0.5 mg/mL
Purification
Size-exclusion chromatography
Storage buffer
PBS
Contains
15mM sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913069
Product Specific Information
This antibody recognizes an extracellular epitope on MHC class I (alpha + beta2m chains) expressed in various animals.
Target Information
Like their mammalian counterparts, avian MHC Class I molecules, also known as B-F antigens, consist of a highly polymorphic alpha-chain noncovalently bound to the invariant beta2-microglobulin subunit. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. The monoclonal antibody F21-2 also reacts with turkey MHC Class I.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A29 protein; antigen presenting molecule; HLA A; HLA class I antigen; HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, A-30 alpha chain; HLA class I histocompatibility antigen, A-33 alpha chain; HLA class I histocompatibility antigen, A-74 alpha chain; HLA locus; HLA-A; HLA-A locus alpha 2 domain; HLA-A null; HLA-Aw33.1; Human leukocyte antigen A; leukocyte antigen class I-A; MCH class I antigen; MHC class 1 antigen; MHC class I anti; MHC Class I antigen; MHC class I antigen A*30; MHC class I antigen A*33; MHC class I antigen A*74; MHC class I antigen heavy chain; MHC class I antigen HLA-A heavy chain; MHC class I antigen HLA-A33; MHC class I antigen null protein; MHC class I antigene; MHC class II antigen; MHC classI antigen; ovar-MHCI-B564; ovar-MHCI-D5; ovar-MHCI-F12; truncated MHC class I antigen
Gene Aliases: Aw-33; Aw-74; HLA-A; HLA-A11; HLA-A33; HLA-DQB1; HLA-DRB1; HLAA; Ovar-I
UniProt ID: (Human) P04439
Entrez Gene ID: (Human) 3105, (Sheep) 101108963, (Sheep) 100171394
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
viral process
antigen processing and presentation
regulation of immune response
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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