Product References
CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases.
The Journal of experimental medicine
Zhang B,Zhang Y,Xiong L,Li Y,Zhang Y,Zhao J,Jiang H,Li C,Liu Y,Liu X,Liu H,Ping YF,Zhang QC,Zhang Z,Bian XW,Zhao Y,Hu X
48-5321-82 was used in Flow cytometry/Cell sorting to henotypically and molecularly characterize CD127-imprinted functional heterogeneity of human inflammatory monocytes with direct relevance for inflammatory diseases.
Mon Feb 07 00:00:00 UTC 2022
WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues.
Developmental cell
Gaertner F,Reis-Rodrigues P,de Vries I,Hons M,Aguilera J,Riedl M,Leithner A,Tasciyan S,Kopf A,Merrin J,Zheden V,Kaufmann WA,Hauschild R,Sixt M
48-5321-82 was used in Flow Cytometry to show that the actin cortex of leukocytes is mechanoresponsive and that this responsiveness requires neither force sensing via the nucleus nor adhesive interactions with a substrate.
Mon Jan 10 00:00:00 UTC 2022
Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis.
PLoS pathogens
Cowan MN,Kovacs MA,Sethi I,Babcock IW,Still K,Batista SJ,O'Brien CA,Thompson JA,Sibley LA,Labuzan SA,Harris TH
48-5321-82 was used in Flow cytometry/Cell sorting to report that abrogation of STAT1 signaling in microglia, the resident immune cells of the CNS, is sufficient to induce a loss of parasite control in the CNS and susceptibility to toxoplasmic encephalitis during the early stages of chronic infection.
Thu Sep 01 00:00:00 UTC 2022
Intratracheal Administration of Acyl Coenzyme A Acyltransferase-1 Inhibitor K-604 Reduces Pulmonary Inflammation Following Bleomycin-Induced Lung Injury.
The Journal of pharmacology and experimental therapeutics
Stevenson ER,Wilkinson ML,Abramova E,Guo C,Gow AJ
48-5321-82 was used in Flow cytometry/Cell sorting to suggest that inhibition of Acat-1 in the lung improves acute lung injury outcomes.
Thu Sep 01 00:00:00 UTC 2022
A novel ZsGreen knock-in melanoma cell line reveals the function of CD11b in tumor phagocytosis.
Immunology and cell biology
Zhang L,Feng X,Shen Y,Wang Y,Liu Z,Ma Y,Gu Y,Guo G,Duan L,Lu L,Liang Y,Lawrence T,Huang R
48-5321-82 was used in Flow cytometry/Cell sorting to demonstrate that the ZsGreen-expressing YUMM1.7 melanoma model provides a valuable tool for the study of phagocytosis in vivo.
Sat Oct 01 00:00:00 UTC 2022
Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation.
Cell reports
Gros M,Segura E,Rookhuizen DC,Baudon B,Heurtebise-Chrétien S,Burgdorf N,Maurin M,Kapp EA,Simpson RJ,Kozik P,Villadangos JA,Bertrand MJM,Burbage M,Amigorena S
48-5321-82 was used in Flow cytometry/Cell sorting to demonstrate that membrane repair proves crucial in containing antigen export to the cytosol and cross-presentation in cDCs.
Tue Aug 16 00:00:00 UTC 2022
Immunomodulatory Role of Surfactant Protein-D in a Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Model.
Frontiers in immunology
Ganguly K,Kishore U,Metkari SM,Madan T
48-5321-82 was used in flow cytometry to evaluate the expression of Surfactant protein D in early and advanced stages of Prostate cancer using transgenic adenocarcinoma of mouse prostate (TRAMP) model.
Tue Jul 26 00:00:00 UTC 2022
Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade.
Cancer discovery
Lander VE,Belle JI,Kingston NL,Herndon JM,Hogg GD,Liu X,Kang LI,Knolhoff BL,Bogner SJ,Baer JM,Zuo C,Borcherding NC,Lander DP,Mpoy C,Scott J,Zahner M,Rogers BE,Schwarz JK,Kim H,DeNardo DG
48-5321-82 was used in Flow Cytometry to show that FAK inhibition allows RT to prime tumor immunity and unlock responsiveness to checkpoint immunotherapy.
Fri Dec 02 00:00:00 UTC 2022
Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14.
eLife
Tomasek K,Leithner A,Glatzova I,Lukesch MS,Guet CC,Sixt M
48-5321-82 was used in flow cytometry to identify CD14, the major co-receptor for lipopolysaccharide detection, on mouse dendritic cells (DCs) as a binding partner of FimH, the protein located at the tip of the type 1 pilus of Escherichia coli.
Tue Jul 26 00:00:00 UTC 2022
DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential.
Developmental cell
Frederico B,Martins I,Chapela D,Gasparrini F,Chakravarty P,Ackels T,Piot C,Almeida B,Carvalho J,Ciccarelli A,Peddie CJ,Rogers N,Briscoe J,Guillemot F,Schaefer AT,Saúde L,Reis e Sousa C
48-5321-82 was used in Flow cytometry/Cell sorting to report that DNGR-1 lineage tracing in mice identifies an ependymal cell subset, wherein resides latent regenerative potential.
Mon Aug 22 00:00:00 UTC 2022
Endometrial Epithelial ARID1A Is Required for Uterine Immune Homeostasis during Early Pregnancy.
International journal of molecular sciences
Marquardt RM,Ahn SH,Reske JJ,Chandler RL,Petroff MG,Kim TH,Jeong JW
48-5321-82 was used in Flow cytometry/Cell sorting to demonstrate a role for endometrial epithelial ARID1A in suppressing inflammation and maintaining uterine immune homeostasis, which are required for successful pregnancy and gynecological health.
Sat May 28 00:00:00 UTC 2022
Protocol to assess the tolerogenic properties of adoptively transferred dendritic cells during murine experimental autoimmune encephalomyelitis.
STAR protocols
Vogel A,Kerndl M,Schabbauer G,Sharif O
48-5321-82 was used in Flow Cytometry experiments to provide a step-by-step instruction for EAE induction, antigen-loaded bone-marrow-derived-DC (BM-DC) generation, adoptive cell transfer, and analysis of DC-mediated changes in regulatory T cell populations.
Fri Sep 16 00:00:00 UTC 2022
Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.
Science advances
Poh AR,Love CG,Chisanga D,Steer JH,Baloyan D,Chopin M,Nutt S,Rautela J,Huntington ND,Etemadi N,O'Brien M,O'Keefe R,Ellies LG,Macri C,Mintern JD,Whitehead L,Gangadhara G,Boon L,Chand AL,Lowell CA,Shi W,Pixley FJ,Ernst M
48-5321-82 was used in Flow cytometry/Cell sorting to suggest that therapeutic targeting of HCK activity enhances response to immunotherapy by simultaneously stimulating immune cell activation and inhibiting the immunosuppressive tumor microenvironment.
Fri Jun 24 00:00:00 UTC 2022
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.
eLife
Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH
48-5321-82 was used in Flow cytometry/Cell sorting to reveal that CNS lymphatic drainage supports the development of peripheral T cell responses against T. gondii but remains dispensable for immune protection of the brain.
Wed Dec 21 00:00:00 UTC 2022
JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction.
Cell reports
Vogel A,Martin K,Soukup K,Halfmann A,Kerndl M,Brunner JS,Hofmann M,Oberbichler L,Korosec A,Kuttke M,Datler H,Kieler M,Musiejovsky L,Dohnal A,Sharif O,Schabbauer G
48-5321-82 was used in Flow Cytometry to conclude that DC-intrinsic JAK1 promotes peripheral tolerance, suggesting potential unwarranted DC-mediated effects of Jakinibs in autoimmune diseases.
Tue Feb 22 00:00:00 UTC 2022
Lung fibrogenic microenvironment in mouse reconstitutes human alveolar structure and lung tumor.
iScience
Miyata R,Hasegawa K,Menju T,Yoshizawa A,Watanabe A,Hirai T,Date H,Sato A
48-5321-82 was used in Flow cytometry/Cell sorting to propose epithelial cell-targeted therapy in pulmonary fibrosis and the establishment of patient-derived xenografts for precision medicine in lung cancer.
Fri Sep 16 00:00:00 UTC 2022
Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses.
eLife
Lundahl MLE,Mitermite M,Ryan DG,Case S,Williams NC,Yang M,Lynch RI,Lagan E,Lebre FM,Gorman AL,Stojkovic B,Bracken AP,Frezza C,Sheedy FJ,Scanlan EM,O'Neill LAJ,Gordon SV,Lavelle EC
48-5321-82 was used in Flow cytometry/Cell sorting to demonstrate that activation with IL-4 and IL-13 counterintuitively induces protective innate memory against mycobacterial challenge.
Thu Sep 29 00:00:00 UTC 2022
PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis.
Frontiers in immunology
Kuttke M,Hromadová D,Yildirim C,Brunner JS,Vogel A,Paar H,Peters S,Weber M,Hofmann M,Kerndl M,Kieler M,Datler H,Musiejovsky L,Salzmann M,Lang M,Soukup K,Halfmann A,Sharif O,Schabbauer G
48-5321-82 was used in Flow cytometry/Cell sorting to show that the PI3K signaling pathway in dendritic cells contributes to disease pathology by promoting IL-6 mediated Th1 responses.
Mon May 09 00:00:00 UTC 2022
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota.
Cell
Lima-Junior DS,Krishnamurthy SR,Bouladoux N,Collins N,Han SJ,Chen EY,Constantinides MG,Link VM,Lim AI,Enamorado M,Cataisson C,Gil L,Rao I,Farley TK,Koroleva G,Attig J,Yuspa SH,Fischbach MA,Kassiotis G,Belkaid Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu Jul 08 00:00:00 UTC 2021
Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects.
Basic research in cardiology
Frenis K,Helmstädter J,Ruan Y,Schramm E,Kalinovic S,Kröller-Schön S,Bayo Jimenez MT,Hahad O,Oelze M,Jiang S,Wenzel P,Sommer CJ,Frauenknecht KBM,Waisman A,Gericke A,Daiber A,Münzel T,Steven S
48-5321 was used in Flow cytometry/Cell sorting to determine the role of myeloid cells in the vascular vs. cerebral consequences of exposure to aircraft noise.
Fri Apr 30 00:00:00 UTC 2021
Regionally diverse astrocyte subtypes and their heterogeneous response to EAE.
Glia
Borggrewe M,Grit C,Vainchtein ID,Brouwer N,Wesseling EM,Laman JD,Eggen BJL,Kooistra SM,Boddeke EWGM
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunohistochemistry
Sat May 01 00:00:00 UTC 2021
CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages.
Immune network
Sim H,Jeong D,Kim HI,Pak S,Thapa B,Kwon HJ,Lee K
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu Apr 01 00:00:00 UTC 2021
Prostaglandin E2 serves a dual role in regulating the migration of dendritic cells.
International journal of molecular medicine
Diao G,Huang J,Zheng X,Sun X,Tian M,Han J,Guo J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Fri Jan 01 00:00:00 UTC 2021
Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma.
Scientific reports
Mittal A,Wang M,Vidyarthi A,Yanez D,Pizzurro G,Thakral D,Tracy E,Colegio OR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Mon May 24 00:00:00 UTC 2021
Transgene distribution and immune response after ultrasound delivery of rAAV9 and PHP.B to the brain in a mouse model of amyloidosis.
Molecular therapy. Methods & clinical development
Kofoed RH,Heinen S,Silburt J,Dubey S,Dibia CL,Maes M,Simpson EM,Hynynen K,Aubert I
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunocytochemistry
Fri Dec 10 00:00:00 UTC 2021
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Cell reports
Budhu S,Giese R,Gupta A,Fitzgerald K,Zappasodi R,Schad S,Hirschhorn D,Campesato LF,De Henau O,Gigoux M,Liu C,Mazo G,Deng L,Barker CA,Wolchok JD,Merghoub T
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Tue Jan 12 00:00:00 UTC 2021
Wip1 regulates the immunomodulatory effects of murine mesenchymal stem cells in type 1 diabetes mellitus via targeting IFN-α/BST2.
Cell death discovery
Zhou N,Liu W,Zhang W,Liu Y,Li X,Wang Y,Zheng R,Zhang Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Fri Oct 29 00:00:00 UTC 2021
Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma.
Journal for immunotherapy of cancer
Que Y,Zhang XL,Liu ZX,Zhao JJ,Pan QZ,Wen XZ,Xiao W,Xu BS,Hong DC,Guo TH,Shen LJ,Fan WJ,Chen HY,Weng DS,Xu HR,Zhou PH,Zhang YZ,Niu XH,Zhang X
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Mon Feb 01 00:00:00 UTC 2021
PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.
Frontiers in immunology
Lv N,Jin S,Liang Z,Wu X,Kang Y,Su L,Dong Y,Wang B,Ma T,Shi L
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Mon Feb 28 00:00:00 UTC 2022
Systemic Inflammation Accelerates Changes in Microglial and Synaptic Markers in an Experimental Model of Chronic Neurodegeneration.
Frontiers in neuroscience
Chouhan JK,Püntener U,Booth SG,Teeling JL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunohistochemistry
Fri May 10 00:00:00 UTC 2024
Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway.
Journal of neuroinflammation
Duan RN,Yang CL,Du T,Liu A,Wang AR,Sun WJ,Li X,Li JX,Yan CZ,Liu QJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Mon Jun 28 00:00:00 UTC 2021
Combined OX40 Agonist and PD-1 Inhibitor Immunotherapy Improves the Efficacy of Vascular Targeted Photodynamic Therapy in a Urothelial Tumor Model.
Molecules (Basel, Switzerland)
Alvim RG,Georgala P,Nogueira L,Somma AJ,Nagar K,Thomas J,Alvim L,Riegel A,Hughes C,Chen J,Reis AB,Lebdai S,Scherz A,Zanganeh S,Gardner R,Kim K,Coleman JA
48-5321-82 was used in Flow Cytometry to study the efficacy of the vascular targeted photodynamic therapy in combination with concurrent PD-1 inhibitor/OX40 agonist immunotherapy in a urothelial tumor-bearing model.
Sat Jun 19 00:00:00 UTC 2021
Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure.
Scientific reports
Flamant M,Mougenot N,Balse E,Le Fèvre L,Atassi F,Gautier EL,Le Goff W,Keck M,Nadaud S,Combadière C,Boissonnas A,Pavoine C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu Sep 09 00:00:00 UTC 2021
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.
Frontiers in immunology
Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Mon Jul 05 00:00:00 UTC 2021
Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia.
Theranostics
Xiong H,Mancini M,Gobert M,Shen S,Furtado GC,Lira SA,Parkhurst CN,Garambois V,Brengues M,Tadokoro CE,Trimarchi T,Gómez-López G,Singh A,Khiabanian H,Minuzzo S,Indraccolo S,Lobry C,Aifantis I,Herranz D,Lafaille JJ,Maraver A
48-5321-82 was used in Flow cytometry/Cell sorting to find that DLL4 expression in human leukemic cells can be a source of Notch activity in T-ALL, and the spleen plays a major role in a genetic mouse model of DLL4-driven T-ALL.
Mon Aug 16 00:00:00 UTC 2021
Dendritic cell entry to lymphatic capillaries is orchestrated by CD44 and the hyaluronan glycocalyx.
Life science alliance
Johnson LA,Banerji S,Lagerholm BC,Jackson DG
48-5321 was used in Flow cytometry/Cell sorting to show that hyaluronan is anchored and spatially organized into a 400-500 nm dense glycocalyx by the leukocyte receptor CD44.
Sat May 01 00:00:00 UTC 2021
The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching.
Immunity
Xu J,Zanvit P,Hu L,Tseng PY,Liu N,Wang F,Liu O,Zhang D,Jin W,Guo N,Han Y,Yin J,Cain A,Hoon MA,Wang S,Chen W
48-5321 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying itching associated with cutaneous wound healing, focusing on the contribution of soluble factors released during healing.
Tue Aug 18 00:00:00 UTC 2020
Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair.
Cell stem cell
Shook BA,Wasko RR,Mano O,Rutenberg-Schoenberg M,Rudolph MC,Zirak B,Rivera-Gonzalez GC,López-Giráldez F,Zarini S,Rezza A,Clark DA,Rendl M,Rosenblum MD,Gerstein MB,Horsley V
48-5321-82 was used in Flow Cytometry to identify an essential role for adipocyte lipolysis in regulating inflammation and repair after injury in skin.
Thu Jun 04 00:00:00 UTC 2020
Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.
EMBO molecular medicine
Menga A,Serra M,Todisco S,Riera-Domingo C,Ammarah U,Ehling M,Palmieri EM,Di Noia MA,Gissi R,Favia M,Pierri CL,Porporato PE,Castegna A,Mazzone M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Wed Oct 07 00:00:00 UTC 2020
The FBW7-MCL-1 axis is key in M1 and M2 macrophage-related colon cancer cell progression: validating the immunotherapeutic value of targeting PI3Kγ.
Experimental & molecular medicine
Lee YS,Song SJ,Hong HK,Oh BY,Lee WY,Cho YB
48-5321 was used in Flow cytometry/Cell sorting to suggest that macrophage PI3Kγ may be a promising target for immunotherapy in colon cancer.
Fri May 01 00:00:00 UTC 2020
Impaired phagocytic function in CX3CR1+ tissue-resident skeletal muscle macrophages prevents muscle recovery after influenza A virus-induced pneumonia in old mice.
Aging cell
Runyan CE,Welch LC,Lecuona E,Shigemura M,Amarelle L,Abdala-Valencia H,Joshi N,Lu Z,Nam K,Markov NS,McQuattie-Pimentel AC,Piseaux-Aillon R,Politanska Y,Sichizya L,Watanabe S,Williams KJN,Budinger GRS,Sznajder JI,Misharin AV
48-5321 was used in Flow cytometry/Cell sorting to suggest that a loss of phagocytic function in a CX3CR1+ tissue-resident skeletal muscle macrophage population in old mice precludes satellite cell proliferation and recovery of skeletal muscle function after influenza A pneumonia.
Tue Sep 01 00:00:00 UTC 2020
PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling-Brief Report.
Arteriosclerosis, thrombosis, and vascular biology
Lu S,Strand KA,Mutryn MF,Tucker RM,Jolly AJ,Furgeson SB,Moulton KS,Nemenoff RA,Weiser-Evans MCM
48-5321 was used in Flow cytometry/Cell sorting to show treatment of pathological vascular fibrosis could be mediated by pharmacological upregulation of PTEN.
Sat Feb 01 00:00:00 UTC 2020
MALT1 targeting suppresses CARD14-induced psoriatic dermatitis in mice.
EMBO reports
Van Nuffel E,Staal J,Baudelet G,Haegman M,Driege Y,Hochepied T,Afonina IS,Beyaert R
48-5321-82 was used in Flow Cytometry to investigate if inducible keratinocyte-specific expression of CARD14E138A in mice rapidly induces epidermal thickening and inflammation as well as increased expression of several genes associated with psoriasis in humans.
Fri Jul 03 00:00:00 UTC 2020
Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells.
Glia
Aires ID,Ribeiro-Rodrigues T,Boia R,Catarino S,Girão H,Ambrósio AF,Santiago AR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunocytochemistry
Tue Dec 01 00:00:00 UTC 2020
E6‑regulated overproduction of prostaglandin E2 may inhibit migration of dendritic cells in human papillomavirus 16‑positive cervical lesions.
International journal of oncology
Huang J,Diao G,Zhang Q,Chen Y,Han J,Guo J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Wed Apr 01 00:00:00 UTC 2020
Pyruvate kinase M2 in lung APCs regulates Alternaria-induced airway inflammation.
Immunobiology
Jaiswal AK,Makhija S,Stahr N,Sandey M,Suryawanshi A,Mishra A
48-5321-82 was used in Flow Cytometry to support a model in which Alternaria sensitization in airways induce a circuitry of glycolysis and PKM2 regulation that confers an acute activation of APCs in the lung, whose targeting might represent a strategy for asthma treatment.
Wed Jul 01 00:00:00 UTC 2020
IFN-β signalling regulates RAW 264.7 macrophage activation, cytokine production, and killing activity.
Innate immunity
Karimi Y,Giles EC,Vahedi F,Chew MV,Nham T,Loukov D,Lee AJ,Bowdish DM,Ashkar AA
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Wed Apr 01 00:00:00 UTC 2020
Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Wed Apr 01 00:00:00 UTC 2020
Optimized Protocol for Isolation of Small Extracellular Vesicles from Human and Murine Lymphoid Tissues.
International journal of molecular sciences
Bordas M,Genard G,Ohl S,Nessling M,Richter K,Roider T,Dietrich S,Maaß KK,Seiffert M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Tue Aug 04 00:00:00 UTC 2020
Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis.
JCI insight
Lu S,Jolly AJ,Strand KA,Dubner AM,Mutryn MF,Moulton KS,Nemenoff RA,Majesky MW,Weiser-Evans MC
48-5321 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms regulating the heterogeneity and behavior of resident vascular adventitial SCA1+ progenitor (AdvSca1) cells in homeostasis and injury responses.
Thu Dec 03 00:00:00 UTC 2020
Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis.
JCI insight
Lu S,Jolly AJ,Strand KA,Dubner AM,Mutryn MF,Moulton KS,Nemenoff RA,Majesky MW,Weiser-Evans MC
48-5321 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms regulating the heterogeneity and behavior of resident vascular adventitial SCA1+ progenitor (AdvSca1) cells in homeostasis and injury responses.
Thu Dec 03 00:00:00 UTC 2020
Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.
Cell reports
Dokoshi T,Zhang LJ,Li F,Nakatsuji T,Butcher A,Yoshida H,Shimoda M,Okada Y,Gallo RL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Tue Jan 07 00:00:00 UTC 2020
Skeletal muscle healing by M1-like macrophages produced by transient expression of exogenous GM-CSF.
Stem cell research & therapy
Martins L,Gallo CC,Honda TSB,Alves PT,Stilhano RS,Rosa DS,Koh TJ,Han SW
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Fri Nov 06 00:00:00 UTC 2020
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.
Nature communications
Campesato LF,Budhu S,Tchaicha J,Weng CH,Gigoux M,Cohen IJ,Redmond D,Mangarin L,Pourpe S,Liu C,Zappasodi R,Zamarin D,Cavanaugh J,Castro AC,Manfredi MG,McGovern K,Merghoub T,Wolchok JD
48-5321 was used in Flow cytometry/Cell sorting to show that the AHR pathway is selectively active in IDO/TDO-overexpressing tumors and is associated with resistance to immune checkpoint inhibitors.
Tue Aug 11 00:00:00 UTC 2020
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.
Nature communications
Campesato LF,Budhu S,Tchaicha J,Weng CH,Gigoux M,Cohen IJ,Redmond D,Mangarin L,Pourpe S,Liu C,Zappasodi R,Zamarin D,Cavanaugh J,Castro AC,Manfredi MG,McGovern K,Merghoub T,Wolchok JD
48-5321 was used in Flow cytometry/Cell sorting to show that the AHR pathway is selectively active in IDO/TDO-overexpressing tumors and is associated with resistance to immune checkpoint inhibitors.
Tue Aug 11 00:00:00 UTC 2020
RON Expression Mediates Lipopolysaccharide-Mediated Dendritic Cell Maturation via March-I.
Frontiers in cellular and infection microbiology
Huang L,Fang X,Zhang X,Wu W,Yao H,Fang Q
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunoprecipitation
Sun Apr 02 00:00:00 UTC 2023
GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype.
Cells
Wang L,Li Y,Wang X,Wang P,Essandoh K,Cui S,Huang W,Mu X,Liu Z,Wang Y,Peng T,Fan GC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Fri Jan 03 00:00:00 UTC 2020
MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarization.
International journal of biological sciences
Zhu X,Liu H,Zhang Z,Wei R,Zhou X,Wang Z,Zhao L,Guo Q,Zhang Y,Chu C,Wang L,Li X
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Fri Nov 12 00:00:00 UTC 2021
Immunomodulatory Effects of Recombinant Mycobacterium smegmatis Expressing Antigen-85B Epitopes in Infected J774A.1 Murine Macrophages.
Pathogens (Basel, Switzerland)
Kadir NA,Acosta A,Sarmiento ME,Norazmi MN
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Sun Nov 29 00:00:00 UTC 2020
Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms.
Journal for immunotherapy of cancer
Neuwelt AJ,Kimball AK,Johnson AM,Arnold BW,Bullock BL,Kaspar RE,Kleczko EK,Kwak JW,Wu MH,Heasley LE,Doebele RC,Li HY,Nemenoff RA,Clambey ET
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Wed Apr 01 00:00:00 UTC 2020
Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.
Scientific reports
Alkhani A,Levy CS,Tsui M,Rosenberg KA,Polovina K,Mattis AN,Mack M,Van Dyken S,Wang BM,Maher JJ,Nijagal A
48-5321 was used in Flow cytometry/Cell sorting to demonstrate that Ly6cLo non-classical monocytes promote resolution of RRV-mediated perinatal liver infammation in both the physiologic environment of the late gestation fetus, and in the neonatal pup.
Tue Apr 28 00:00:00 UTC 2020
Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.
Scientific reports
Alkhani A,Levy CS,Tsui M,Rosenberg KA,Polovina K,Mattis AN,Mack M,Van Dyken S,Wang BM,Maher JJ,Nijagal A
48-5321 was used in Flow cytometry/Cell sorting to demonstrate that Ly6cLo non-classical monocytes promote resolution of RRV-mediated perinatal liver infammation in both the physiologic environment of the late gestation fetus, and in the neonatal pup.
Tue Apr 28 00:00:00 UTC 2020
Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103+CD11b+ Dendritic Cells.
Frontiers in immunology
Ko HJ,Hong SW,Verma R,Jung J,Lee M,Kim N,Kim D,Surh CD,Kim KS,Rudra D,Im SH
48-5321 was used in Flow cytometry/Cell sorting to reveal previously underappreciated role of dietary glucose concentration in establishing regulatory properties in intestinal DCs, thereby extending a potential therapeutic module against intestinal inflammation.
Mon Apr 19 00:00:00 UTC 2021
Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103+CD11b+ Dendritic Cells.
Frontiers in immunology
Ko HJ,Hong SW,Verma R,Jung J,Lee M,Kim N,Kim D,Surh CD,Kim KS,Rudra D,Im SH
48-5321 was used in Flow cytometry/Cell sorting to reveal previously underappreciated role of dietary glucose concentration in establishing regulatory properties in intestinal DCs, thereby extending a potential therapeutic module against intestinal inflammation.
Mon Apr 19 00:00:00 UTC 2021
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Mon May 04 00:00:00 UTC 2020
TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg.
Cell reports
Dolina JS,Lee J,Griswold RQ,Labarta-Bajo L,Kannan S,Greenbaum JA,Bahia El Idrissi N,Pont MJ,Croft M,Schoenberger SP
48-5321 was used in Flow cytometry/Cell sorting to resolve long-standing questions regarding the conditional requirement for TH amongst pathogens and reveal a remarkable degree of plasticity in the function of CD4+ T cells, which can be quickly converted to Tregin vivo by infection-mediated immune modulation.
Tue Apr 07 00:00:00 UTC 2020
Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting in CD8+ T Cell Memory and Delayed Tumor Progression.
International journal of nanomedicine
Darling R,Senapati S,Christiansen J,Liu L,Ramer-Tait AE,Narasimhan B,Wannemuehler M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Mon Dec 07 00:00:00 UTC 2020
Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy.
Journal for immunotherapy of cancer
Gao H,Wu Y,Shi J,Zhang X,Liu T,Hu B,Jia B,Wan Y,Liu Z,Wang F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Sun Nov 01 00:00:00 UTC 2020
CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner.
Theranostics
Zhang QF,Li J,Jiang K,Wang R,Ge JL,Yang H,Liu SJ,Jia LT,Wang L,Chen BL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Tue Jun 01 00:00:00 UTC 2021
Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.
Scientific reports
Hrdý J,Alard J,Couturier-Maillard A,Boulard O,Boutillier D,Delacre M,Lapadatescu C,Cesaro A,Blanc P,Pot B,Ryffel B,Chamaillard M,Grangette C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Tue Mar 24 00:00:00 UTC 2020
Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity.
Nature communications
Kimura S,Nakamura Y,Kobayashi N,Shiroguchi K,Kawakami E,Mutoh M,Takahashi-Iwanaga H,Yamada T,Hisamoto M,Nakamura M,Udagawa N,Sato S,Kaisho T,Iwanaga T,Hase K
48-5321 was used in Flow cytometry/Cell sorting to identify that the balance between infectious risk and the ability to perform immunosurveillance at the mucosal surface is dependent on osteprotegerin-dependent self-regulation of M cell differentiation.
Mon Jan 13 00:00:00 UTC 2020
Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.
STAR protocols
Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Fri Jun 19 00:00:00 UTC 2020
Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.
Scientific reports
Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Mon Jun 29 00:00:00 UTC 2020
The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration.
Molecular therapy. Nucleic acids
Van Hoecke L,Roose K,Ballegeer M,Zhong Z,Sanders NN,De Koker S,Saelens X,Van Lint S
48-5321-82 was used in Flow cytometry/Cell sorting to demonstrate that the opposing roles of type I type I interferon signaling on the magnitude of the vaccine-evoked T cell responses is dependent on the route of mRNA-lipoplex administration and is regulated at the level of the T cells rather than indirectly through modulation of dendritic cell function.
Fri Dec 04 00:00:00 UTC 2020
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.
Nature communications
Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A
48-5321 was used in Flow cytometry/Cell sorting to study whether MP CD4+ T cells are functionally heterogeneous and, if so, what signals specify the differentiation of MP cell subpopulations under homeostatic conditions.
Mon Jul 06 00:00:00 UTC 2020
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
48-5321-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 UTC 2019
Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.
Cell host & microbe
Leech JM,Dhariwala MO,Lowe MM,Chu K,Merana GR,Cornuot C,Weckel A,Ma JM,Leitner EG,Gonzalez JR,Vasquez KS,Diep BA,Scharschmidt TC
48-5321-82 was used in Flow cytometry/Cell sorting to study how skin colonization by commensal Staphylococcus epidermidis facilitates immune tolerance preferentially in neonates via induction of antigen-specific regulatory T cells.
Wed Dec 11 00:00:00 UTC 2019
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
The Journal of clinical investigation
Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Tue Aug 13 00:00:00 UTC 2019
Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency.
The Journal of allergy and clinical immunology
Dudeck J,Froebel J,Kotrba J,Lehmann CHK,Dudziak D,Speier S,Nedospasov SA,Schraven B,Dudeck A
48-5321 was used in Flow cytometry/Cell sorting to show peripheral mast cells can modify dendritic cell functionality to influence lymphoid tissue-borne adaptive immunity.
Wed May 01 00:00:00 UTC 2019
Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.
Pain research & management
Sheng WS,Chauhan P,Hu S,Prasad S,Lokensgard JR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Mon Dec 16 00:00:00 UTC 2019
Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice.
Scientific reports
Aires ID,Madeira MH,Boia R,Rodrigues-Neves AC,Martins JM,Ambrósio AF,Santiago AR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunohistochemistry
Wed Nov 20 00:00:00 UTC 2019
MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.
Journal for immunotherapy of cancer
Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu Nov 28 00:00:00 UTC 2019
TIV Vaccination Modulates Host Responses to Influenza Virus Infection that Correlate with Protection against Bacterial Superinfection.
Vaccines
Choi A,Christopoulou I,Saelens X,García-Sastre A,Schotsaert M
48-5321 was used in Flow cytometry/Cell sorting to establish a mouse vaccination model that allows control of disease severity after influenza virus infection despite inefficient induction of virus-neutralizing antibody titers by vaccination.
Thu Sep 12 00:00:00 UTC 2019
Reprogramming the adjuvant properties of aluminum oxyhydroxide with nanoparticle technology.
NPJ vaccines
Orr MT,Khandhar AP,Seydoux E,Liang H,Gage E,Mikasa T,Beebe EL,Rintala ND,Persson KH,Ahniyaz A,Carter D,Reed SG,Fox CB
48-5321-82 was used in Flow Cytometry to determine whether the particle size and aggregated state of aluminum oxyhydroxide affects its adjuvant activity.
Thu Oct 01 00:00:00 UTC 2020
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu Jan 25 00:00:00 UTC 2018
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.
Immunity
Emgård J,Kammoun H,García-Cassani B,Chesné J,Parigi SM,Jacob JM,Cheng HW,Evren E,Das S,Czarnewski P,Sleiers N,Melo-Gonzalez F,Kvedaraite E,Svensson M,Scandella E,Hepworth MR,Huber S,Ludewig B,Peduto L,Villablanca EJ,Veiga-Fernandes H,Pereira JP,Flavell RA,Willinger T
48-5321-82 was used in Flow Cytometry to show that GPR183 promotes lymphoid organ development and indicate that oxysterol-GPR183-dependent positioning within tissues controls ILC3 activity and intestinal homeostasis.
Tue Jan 16 00:00:00 UTC 2018
Non-conventional Inhibitory CD4+Foxp3-PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity.
Cancer cell
Zappasodi R,Budhu S,Hellmann MD,Postow MA,Senbabaoglu Y,Manne S,Gasmi B,Liu C,Zhong H,Li Y,Huang AC,Hirschhorn-Cymerman D,Panageas KS,Wherry EJ,Merghoub T,Wolchok JD
48-5321-82 was used in Flow Cytometry to provide evidence that mouse and human circulating and intra-tumor 4PD1hi inhibit T cell functions in a PD-1/PD-L1 dependent fashion and resemble follicular helper T cell (TFH)-like cells.
Mon Jun 11 00:00:00 UTC 2018
Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.
The Journal of clinical investigation
Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML
48-5321 was used in Flow cytometry/Cell sorting to study the role of blood growth factors in chronic obstructive pulmonary disease.
Fri Jun 01 00:00:00 UTC 2018
An OX40/OX40L interaction directs successful immunity to hepatitis B virus.
Science translational medicine
Publicover J,Gaggar A,Jespersen JM,Halac U,Johnson AJ,Goodsell A,Avanesyan L,Nishimura SL,Holdorf M,Mansfield KG,Judge JB,Koshti A,Croft M,Wakil AE,Rosenthal P,Pai E,Cooper S,Baron JL
48-5321 was used in Flow cytometry/Cell sorting to study the mechanistic action of the immune pathways and cells necessary for HBV immunity and identify potential therapeutic targets for resolving chronic HBV infection.
Wed Mar 21 00:00:00 UTC 2018
Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.
The Journal of experimental medicine
Buxadé M,Huerga Encabo H,Riera-Borrull M,Quintana-Gallardo L,López-Cotarelo P,Tellechea M,Martínez-Martínez S,Redondo JM,Martín-Caballero J,Flores JM,Bosch E,Rodríguez-Fernández JL,Aramburu J,López-Rodríguez C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Mon Nov 05 00:00:00 UTC 2018
Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression.
Cancer research
Kwak JW,Laskowski J,Li HY,McSharry MV,Sippel TR,Bullock BL,Johnson AM,Poczobutt JM,Neuwelt AJ,Malkoski SP,Weiser-Evans MC,Lambris JD,Clambey ET,Thurman JM,Nemenoff RA
48-5321 was used in Flow cytometry/Cell sorting to study the mechanism relating complement activation to tumour progression in multiple immunocompetent orthotopic models of lung cancer.
Mon Jan 01 00:00:00 UTC 2018
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
48-5321-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 UTC 2019
Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination.
Glia
Kim S,Bielawski J,Yang H,Kong Y,Zhou B,Li J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunofluorescence
Thu Mar 01 00:00:00 UTC 2018
Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination.
Glia
Kim S,Bielawski J,Yang H,Kong Y,Zhou B,Li J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunofluorescence
Thu Mar 01 00:00:00 UTC 2018
Age Influences Microglial Activation After Cuprizone-Induced Demyelination.
Frontiers in aging neuroscience
Klein B,Mrowetz H,Barker CM,Lange S,Rivera FJ,Aigner L
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunofluorescence
Thu Oct 01 00:00:00 UTC 2020
FACS isolation of live mouse eosinophils at high purity via a protocol that does not target Siglec F.
Journal of immunological methods
Geslewitz WE,Percopo CM,Rosenberg HF
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu Mar 01 00:00:00 UTC 2018
Lin-CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade.
Nature communications
Flores CT,Wildes TJ,Drake JA,Moore GL,Dean BD,Abraham RS,Mitchell DA
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Wed Oct 17 00:00:00 UTC 2018
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation.
Nature communications
Bonacina F,Coe D,Wang G,Longhi MP,Baragetti A,Moregola A,Garlaschelli K,Uboldi P,Pellegatta F,Grigore L,Da Dalt L,Annoni A,Gregori S,Xiao Q,Caruso D,Mitro N,Catapano AL,Marelli-Berg FM,Norata GD
48-5321 was used in Flow cytometry/Cell sorting to show that apolipoprotein E deficiency leads to the accumulation of cholesterol in the cell membrane of dendritic cells, resulting in enhanced MHC-II-dependent antigen presentation and CD4+ T-cell activation.
Mon Aug 06 00:00:00 UTC 2018
CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema.
Nature communications
García Nores GD,Ly CL,Cuzzone DA,Kataru RP,Hespe GE,Torrisi JS,Huang JJ,Gardenier JC,Savetsky IL,Nitti MD,Yu JZ,Rehal S,Mehrara BJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu May 17 00:00:00 UTC 2018
Low-Dose Radiotherapy Has No Harmful Effects on Key Cells of Healthy Non-Inflamed Joints.
International journal of molecular sciences
Deloch L,Rückert M,Fietkau R,Frey B,Gaipl US
48-5321 was used in Flow cytometry/Cell sorting to show that low-dose radiotherapy with particularly a single dose of 0.5 Gray has no harmful effects on cells of healthy joints.
Tue Oct 16 00:00:00 UTC 2018
Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection.
Nature communications
Rolot M,Dougall AM,Chetty A,Javaux J,Chen T,Xiao X,Machiels B,Selkirk ME,Maizels RM,Hokke C,Denis O,Brombacher F,Vanderplasschen A,Gillet L,Horsnell WGC,Dewals BG
48-5321 was used in Flow cytometry/Cell sorting to study whether helminth-induced type 2 immunity functionally affects the T virtual memory cell compartment.
Tue Oct 30 00:00:00 UTC 2018
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.
Cell
Ali N,Zirak B,Rodriguez RS,Pauli ML,Truong HA,Lai K,Ahn R,Corbin K,Lowe MM,Scharschmidt TC,Taravati K,Tan MR,Ricardo-Gonzalez RR,Nosbaum A,Bertolini M,Liao W,Nestle FO,Paus R,Cotsarelis G,Abbas AK,Rosenblum MD
48-5321 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells in hair follicles and hair follicle stem cell biology.
Thu Jun 01 00:00:00 UTC 2017
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.
Immunity
Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY
48-5321 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.
Tue Nov 21 00:00:00 UTC 2017
T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node.
Immunity
Baratin M,Simon L,Jorquera A,Ghigo C,Dembele D,Nowak J,Gentek R,Wienert S,Klauschen F,Malissen B,Dalod M,Bajénoff M
48-5321 was used in Flow cytometry/Cell sorting to characterise a population of CX3CR1+ MERTK+ cells located in the T cell zone of lymph nodes.
Tue Aug 15 00:00:00 UTC 2017
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.
The Journal of clinical investigation
Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Wed Mar 01 00:00:00 UTC 2017
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
The Journal of experimental medicine
Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG
48-5321 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.
Mon Sep 04 00:00:00 UTC 2017
Developmental origin and maintenance of distinct testicular macrophage populations.
The Journal of experimental medicine
Mossadegh-Keller N,Gentek R,Gimenez G,Bigot S,Mailfert S,Sieweke MH
48-5321-82 was used in Flow Cytometry to investigate the developmental origins and mode of homeostatic maintenance of two distinct testicular macrophages populations.
Mon Oct 02 00:00:00 UTC 2017
Prolonged Deleterious Influences of Chemotherapeutic Agent CPT-11 on Resident Peritoneal Macrophages and B1 Cells.
Frontiers in immunology
Bai WJ,Li CG,Zhang CC,Xu LH,Zeng QZ,Hu B,Hong Z,He XH,Ouyang DY
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Wed Nov 20 00:00:00 UTC 2019
FXYD5 Is an Essential Mediator of the Inflammatory Response during Lung Injury.
Frontiers in immunology
Brazee PL,Soni PN,Tokhtaeva E,Magnani N,Yemelyanov A,Perlman HR,Ridge KM,Sznajder JI,Vagin O,Dada LA
48-5321 was used in Flow cytometry/Cell sorting to confirm that FXYD5 induces a range of pro-inflammatory effects.
Fri Mar 18 00:00:00 UTC 2022
Intestinal Batf3-dependent dendritic cells are required for optimal antiviral T-cell responses in adult and neonatal mice.
Mucosal immunology
Sun T,Rojas OL,Li C,Ward LA,Philpott DJ,Gommerman JL
48-5321 was used in Flow cytometry/Cell sorting to study the dendritic cell subset(s) that provoke antiviral responses within the gut.
Mon May 01 00:00:00 UTC 2017
Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice.
Neurobiology of disease
MacPherson KP,Sompol P,Kannarkat GT,Chang J,Sniffen L,Wildner ME,Norris CM,Tansey MG
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu Jun 01 00:00:00 UTC 2017
Semaphorin 3E Deficiency Exacerbates Airway Inflammation, Hyperresponsiveness, and Remodeling in a Mouse Model of Allergic Asthma.
Journal of immunology (Baltimore, Md. : 1950)
Movassagh H,Shan L,Mohammed A,Halayko AJ,Gounni AS
48-5321 was used in Flow cytometry/Cell sorting to identify Semaphorin 3E as a novel regulatory molecule in allergic asthma that acts upstream of proallergic events.
Wed Mar 01 00:00:00 UTC 2017
Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.
Molecular medicine reports
Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Wed Nov 01 00:00:00 UTC 2017
The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model.
Cancer prevention research (Philadelphia, Pa.)
Dwyer-Nield L,Hickey GA,Friedman M,Choo K,McArthur DG,Tennis MA,New ML,Geraci M,Keith RL
48-5321 was used in Flow cytometry/Cell sorting to study the ability of treprostinil to chemoprevent urethane-induced murine lung adenocarcinoma.
Wed Nov 01 00:00:00 UTC 2017
Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.
Scientific reports
Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunofluorescence
Mon Feb 06 00:00:00 UTC 2017
Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis.
PloS one
McDonald LT,Johnson SD,Russell DL,Young MRI,LaRue AC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Mon Sep 25 00:00:00 UTC 2017
Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury.
Frontiers in cellular neuroscience
Cruz SA,Hari A,Qin Z,Couture P,Huang H,Lagace DC,Stewart AFR,Chen HH
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu Mar 17 00:00:00 UTC 2022
Immunogenicity of Isogenic IgG in Aggregates and Immune Complexes.
PloS one
St Clair JB,Detanico T,Aviszus K,Kirchenbaum GA,Christie M,Carpenter JF,Wysocki LJ
48-5321 was used in Flow cytometry/Cell sorting to analyse CD4 T cell reactions against IgG in various physical states.
Fri Aug 11 00:00:00 UTC 2017
In vivo quantification of quantum dot systemic transport in C57BL/6 hairless mice following skin application post-ultraviolet radiation.
Particle and fibre toxicology
Jatana S,Palmer BC,Phelan SJ,Gelein R,DeLouise LA
48-5321-82 was used in Flow cytometry/Cell sorting to suggest that Langerhans cells can engulf quantum dots in skin, but lymph node transport is both cellular and non-cellular.
Fri Apr 14 00:00:00 UTC 2017
Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.
Nature communications
Rossey I,Gilman MS,Kabeche SC,Sedeyn K,Wrapp D,Kanekiyo M,Chen M,Mas V,Spitaels J,Melero JA,Graham BS,Schepens B,McLellan JS,Saelens X
48-5321 was used in Flow cytometry/Cell sorting to obtain molecules with very high respiratory syncytial virus (RSV)-neutralising activity that could be developed as a therapeutic treatment of RSV infections.
Mon Feb 13 00:00:00 UTC 2017
Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A.
PLoS neglected tropical diseases
Floudas A,Cluxton CD,Fahel J,Khan AR,Saunders SP,Amu S,Alcami A,Fallon PG
48-5321 was used in Flow cytometry/Cell sorting to demonstrate the unique protein composition of the S. mansoni male worm secretome and immunomodulatory activity of S. mansoni Cyclophilin A.
Sun Oct 01 00:00:00 UTC 2017
Boosting the hypoxic response in myeloid cells accelerates resolution of fibrosis and regeneration of the liver in mice.
Oncotarget
Kantari-Mimoun C,Krzywinska E,Castells M,Milien C,Klose R,Meinecke AK,Lemberger U,Mathivet T,Gojkovic M,Schrödter K,Österreicher C,Fandrey J,Rundqvist H,Stockmann C
48-5321 was used in Flow cytometry/Cell sorting to show that the resolution of fibrosis can be accelerated by deleting VHL, a negative regulator of HIFs and VEGF, specifically in myeloid cells in mice.
Tue Feb 28 00:00:00 UTC 2017
Isolation and Identification of Intestinal Myeloid Cells.
Methods in molecular biology (Clifton, N.J.)
Scott CL,Bain CC,Mowat AM
48532182 was used in flow cytometry to identify myeloid cells obtained from mouse intestine.
Wed Jan 31 00:00:00 UTC 2018
Microglial brain region-dependent diversity and selective regional sensitivities to aging.
Nature neuroscience
Grabert K,Michoel T,Karavolos MH,Clohisey S,Baillie JK,Stevens MP,Freeman TC,Summers KM,McColl BW
Tue Mar 01 00:00:00 UTC 2016
CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability.
The Journal of clinical investigation
Ivanov S,Scallan JP,Kim KW,Werth K,Johnson MW,Saunders BT,Wang PL,Kuan EL,Straub AC,Ouhachi M,Weinstein EG,Williams JW,Briseño C,Colonna M,Isakson BE,Gautier EL,Förster R,Davis MJ,Zinselmeyer BH,Randolph GJ
48-5321 was used in Flow cytometry/Cell sorting to investigate the molecular signals that affect lymphatic collecting vessel permeability.
Fri Apr 01 00:00:00 UTC 2016
Microglia are less pro-inflammatory than myeloid infiltrates in the hippocampus of mice exposed to status epilepticus.
Glia
Vinet J,Vainchtein ID,Spano C,Giordano C,Bordini D,Curia G,Dominici M,Boddeke HW,Eggen BJ,Biagini G
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunofluorescence
Mon Aug 01 00:00:00 UTC 2016
Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages.
Glia
Guglielmetti C,Le Blon D,Santermans E,Salas-Perdomo A,Daans J,De Vocht N,Shah D,Hoornaert C,Praet J,Peerlings J,Kara F,Bigot C,Mai Z,Goossens H,Hens N,Hendrix S,Verhoye M,Planas AM,Berneman Z,van der Linden A,Ponsaerts P
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunofluorescence
Thu Dec 01 00:00:00 UTC 2016
Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.
Stem cells translational medicine
Zheng H,Zou W,Shen J,Xu L,Wang S,Fu YX,Fan W
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu Sep 01 00:00:00 UTC 2016
Recruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes.
Journal of leukocyte biology
Lagassé HA,Anidi IU,Craig JM,Limjunyawong N,Poupore AK,Mitzner W,Scott AL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Sun May 01 00:00:00 UTC 2016
Lymphatic endothelial lineage assemblage during corneal lymphangiogenesis.
Laboratory investigation; a journal of technical methods and pathology
Connor AL,Kelley PM,Tempero RM
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunofluorescence
Tue Mar 01 00:00:00 UTC 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Mon Aug 15 00:00:00 UTC 2016
PSM Peptides of Staphylococcus aureus Activate the p38-CREB Pathway in Dendritic Cells, Thereby Modulating Cytokine Production and T Cell Priming.
Journal of immunology (Baltimore, Md. : 1950)
Armbruster NS,Richardson JR,Schreiner J,Klenk J,Günter M,Kretschmer D,Pöschel S,Schenke-Layland K,Kalbacher H,Clark K,Autenrieth SE
48-5321 was used in Flow cytometry/Cell sorting to analyse the effects of phenol-soluble modulin peptides on signaling pathway modulation downstream of TLR2.
Mon Feb 01 00:00:00 UTC 2016
Effects of ketanserin on experimental colitis in mice and macrophage function.
International journal of molecular medicine
Xiao J,Shao L,Shen J,Jiang W,Feng Y,Zheng P,Liu F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Tue Mar 01 00:00:00 UTC 2016
MIF Promotes Classical Activation and Conversion of Inflammatory Ly6C(high) Monocytes into TipDCs during Murine Toxoplasmosis.
Mediators of inflammation
Ruiz-Rosado Jde D,Olguín JE,Juárez-Avelar I,Saavedra R,Terrazas LI,Robledo-Avila FH,Vazquez-Mendoza A,Fernández J,Satoskar AR,Partida-Sánchez S,Rodriguez-Sosa M
48-5321 was used in Flow cytometry/Cell sorting to analyse the role of migration inhibitory factor in the maturation of CD11b(+) and CD8α (+) dendritic cells.
Fri Dec 30 00:00:00 UTC 2016
Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS.
Human vaccines & immunotherapeutics
Xu X,Gao Y,Zhai Z,Zhang S,Shan F,Feng J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Tue Aug 02 00:00:00 UTC 2016
Thiol peroxiredoxin, a novel allergen from Bombyx mori, modulates functions of macrophages and dendritic cells.
American journal of translational research
Wang H,Hu W,Liang Z,Zeng L,Li J,Yan H,Yang P,Liu Z,Wang L
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu Oct 01 00:00:00 UTC 2020
Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model.
Journal of neuroinflammation
Le Blon D,Guglielmetti C,Hoornaert C,Quarta A,Daans J,Dooley D,Lemmens E,Praet J,De Vocht N,Reekmans K,Santermans E,Hens N,Goossens H,Verhoye M,Van der Linden A,Berneman Z,Hendrix S,Ponsaerts P
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunofluorescence
Wed Nov 09 00:00:00 UTC 2016
Stroke sensitivity in the aged: sex chromosome complement vs. gonadal hormones.
Aging
McCullough LD,Mirza MA,Xu Y,Bentivegna K,Steffens EB,Ritzel R,Liu F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Fri Jul 01 00:00:00 UTC 2016
Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration.
eLife
Lopes Pinheiro MA,Kamermans A,Garcia-Vallejo JJ,van Het Hof B,Wierts L,O'Toole T,Boeve D,Verstege M,van der Pol SM,van Kooyk Y,de Vries HE,Unger WW
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu Jun 23 00:00:00 UTC 2016
Allergy Enhances Neurogenesis and Modulates Microglial Activation in the Hippocampus.
Frontiers in cellular neuroscience
Klein B,Mrowetz H,Thalhamer J,Scheiblhofer S,Weiss R,Aigner L
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunofluorescence
Fri Jul 22 00:00:00 UTC 2016
Epidermal RAF prevents allergic skin disease.
eLife
Raguz J,Jeric I,Niault T,Nowacka JD,Kuzet SE,Rupp C,Fischer I,Biggi S,Borsello T,Baccarini M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Tue Jul 19 00:00:00 UTC 2016
Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis.
PloS one
Tengvall S,Eneljung T,Jirholt P,Turesson O,Wing K,Holmdahl R,Kihlberg J,Stern A,Mårtensson IL,Henningsson L,Gustafsson K,Gjertsson I
48-5321 was used in Flow cytometry/Cell sorting to investigate induction of immunological tolerance by lentiviral based gene therapy in a mouse model of rheumatoid arthritis.
Mon Jul 17 00:00:00 UTC 2017
Monomeric annexin A2 is an oxygen-regulated toll-like receptor 2 ligand and adjuvant.
Journal for immunotherapy of cancer
Andersen BM,Xia J,Epstein AL,Ohlfest JR,Chen W,Blazar BR,Pennell CA,Olin MR
48-5321 was used in Flow cytometry/Cell sorting to study the effect of ANXA2m on CD80 and CD86 expression, antigen cross-presentation, and the secretion of various cytokines.
Wed Feb 17 00:00:00 UTC 2016
Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy.
Oncoimmunology
Holmgaard RB,Brachfeld A,Gasmi B,Jones DR,Mattar M,Doman T,Murphy M,Schaer D,Wolchok JD,Merghoub T
Fri Jul 01 00:00:00 UTC 2016
Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.
Nature immunology
Grajales-Reyes GE,Iwata A,Albring J,Wu X,Tussiwand R,Kc W,Kretzer NM,Briseño CG,Durai V,Bagadia P,Haldar M,Schönheit J,Rosenbauer F,Murphy TL,Murphy KM
48-5321 was used in Flow cytometry/Cell sorting to investigate the role of the transcription factors Batf3 and IRF8 in the development of CD8α(+) conventional dendritic cells..
Wed Jul 01 00:00:00 UTC 2015
Adaptive Immune Regulation of Mammary Postnatal Organogenesis.
Developmental cell
Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Mon Sep 14 00:00:00 UTC 2015
Benefits of Neuronal Preferential Systemic Gene Therapy for Neurotransmitter Deficiency.
Molecular therapy : the journal of the American Society of Gene Therapy
Lee NC,Muramatsu S,Chien YH,Liu WS,Wang WH,Cheng CH,Hu MK,Chen PW,Tzen KY,Byrne BJ,Hwu WL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunohistochemistry
Thu Oct 01 00:00:00 UTC 2015
The late endosomal adaptor molecule p14 (LAMTOR2) regulates TGFβ1-mediated homeostasis of Langerhans cells.
The Journal of investigative dermatology
Sparber F,Tripp CH,Komenda K,Scheffler JM,Clausen BE,Huber LA,Romani N,Stoitzner P
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu Jan 01 00:00:00 UTC 2015
Class I myosin Myo1e regulates TLR4-triggered macrophage spreading, chemokine release, and antigen presentation via MHC class II.
European journal of immunology
Wenzel J,Ouderkirk JL,Krendel M,Lang R
48-5321 was used in Flow cytometry/Cell sorting to provide evidence for a non-redundant function of the motor protein Myo1e in the regulation of TLR4-controlled, cytoskeleton-associated functional properties of macrophages and DCs, and in induction of a full MHC-II-restricted adaptive immune response.
Thu Jan 01 00:00:00 UTC 2015
Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Vaeth M,Zee I,Concepcion AR,Maus M,Shaw P,Portal-Celhay C,Zahra A,Kozhaya L,Weidinger C,Philips J,Unutmaz D,Feske S
48-5321 was used in Flow cytometry/Cell sorting to investigate the role of STIM1, STIM2 and SOCE on effector functions of macrophages and dendritic cells, and how these affect CRAC channel inhibition.
Sat Aug 01 00:00:00 UTC 2015
Macrophage-inducible C-type lectin Mincle-expressing dendritic cells contribute to control of splenic Mycobacterium bovis BCG infection in mice.
Infection and immunity
Behler F,Maus R,Bohling J,Knippenberg S,Kirchhof G,Nagata M,Jonigk D,Izykowski N,Mägel L,Welte T,Yamasaki S,Maus UA
48-5321 was used in Flow cytometry/Cell sorting to show that expression of Mincle contributes to the control of splenic Mycobacterium bovis BCG infection in mice.
Thu Jan 01 00:00:00 UTC 2015
Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway.
Molecular medicine reports
Huang L,Kong Y,Wang J,Sun J,Shi Q,Qiu YH
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Tue Sep 01 00:00:00 UTC 2015
Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.
Cell reports
DeFalco T,Potter SJ,Williams AV,Waller B,Kan MJ,Capel B
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Tue Aug 18 00:00:00 UTC 2015
Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.
Cell reports
DeFalco T,Potter SJ,Williams AV,Waller B,Kan MJ,Capel B
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Tue Aug 18 00:00:00 UTC 2015
Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.
Cell reports
DeFalco T,Potter SJ,Williams AV,Waller B,Kan MJ,Capel B
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Tue Aug 18 00:00:00 UTC 2015
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.
Nature communications
Sag D,Cekic C,Wu R,Linden J,Hedrick CC
48-5321 was used in Flow cytometry/Cell sorting to demonstrate that the absence of ABCG1 inhibits tumour growth through modulation of macrophage function within the tumour.
Fri Feb 27 00:00:00 UTC 2015
High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity.
Nature
Schulz MD,Atay C,Heringer J,Romrig FK,Schwitalla S,Aydin B,Ziegler PK,Varga J,Reindl W,Pommerenke C,Salinas-Riester G,Böck A,Alpert C,Blaut M,Polson SC,Brandl L,Kirchner T,Greten FR,Polson SW,Arkan MC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu Oct 23 00:00:00 UTC 2014
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.
Nature
Westphalen K,Gusarova GA,Islam MN,Subramanian M,Cohen TS,Prince AS,Bhattacharya J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunofluorescence
Thu Feb 27 00:00:00 UTC 2014
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Nature immunology
Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD
48-5321 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
Wed Jan 01 00:00:00 UTC 2014
Collective nitric oxide production provides tissue-wide immunity during Leishmania infection.
The Journal of clinical investigation
Olekhnovitch R,Ryffel B,Müller AJ,Bousso P
48-5321 was used in Flow cytometry/Cell sorting to investigate the contribution of cell-intrinsic and cell-extrinsic nitric oxide activity on the control of Leishmania major infection.
Tue Apr 01 00:00:00 UTC 2014
Intravascular staining for discrimination of vascular and tissue leukocytes.
Nature protocols
Anderson KG,Mayer-Barber K,Sung H,Beura L,James BR,Taylor JJ,Qunaj L,Griffith TS,Vezys V,Barber DL,Masopust D
48-5321 was used in Flow cytometry/Cell sorting to outline a protocol for the validation and use of intravascular staining to define innate and adaptive immune cells in mice.
Wed Jan 01 00:00:00 UTC 2014
Blocking junctional adhesion molecule C enhances dendritic cell migration and boosts the immune responses against Leishmania major.
PLoS pathogens
Ballet R,Emre Y,Jemelin S,Charmoy M,Tacchini-Cottier F,Imhof BA
48-5321 was used in Flow cytometry/Cell sorting to illustrate a key role for the vascular adhesion molecule JAM-C in controlling leukocyte migration and subsequent immune events in response to pathogen infections.
Mon Dec 01 00:00:00 UTC 2014
C/EBPβ expression is an independent predictor of overall survival in breast cancer patients by MHCII/CD4-dependent mechanism of metastasis formation.
Oncogenesis
Kurzejamska E,Johansson J,Jirström K,Prakash V,Ananthaseshan S,Boon L,Fuxe J,Religa P
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunohistochemistry
Mon Nov 03 00:00:00 UTC 2014
GM-CSF-licensed CD11b+ lung dendritic cells orchestrate Th2 immunity to Blomia tropicalis.
Journal of immunology (Baltimore, Md. : 1950)
Zhou Q,Ho AW,Schlitzer A,Tang Y,Wong KH,Wong FH,Chua YL,Angeli V,Mortellaro A,Ginhoux F,Kemeny DM
48-5321 was used in Flow cytometry/Cell sorting to identify GM-CSF-licensed CD11b(+) lung DCs as a key component for induction of Th2 responses.
Tue Jul 15 00:00:00 UTC 2014
Tumor-promoting role of TGFβ1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells.
Carcinogenesis
Ravindran A,Mohammed J,Gunderson AJ,Cui X,Glick AB
48-5321 was used in Flow cytometry/Cell sorting to study how TGFβ1 signalling has a tumour-promoting role in UVB-induced skin carcinogenesis, which is mediated in part through its role in UVB-induced migration of dDC and cutaneous inflammation.
Tue Apr 01 00:00:00 UTC 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Mon Jan 05 00:00:00 UTC 2015
BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
Cellular immunology
Bakhru P,Sirisaengtaksin N,Soudani E,Mukherjee S,Khan A,Jagannath C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Wed Jan 01 00:00:00 UTC 2014
BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
Cellular immunology
Bakhru P,Sirisaengtaksin N,Soudani E,Mukherjee S,Khan A,Jagannath C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Wed Jan 01 00:00:00 UTC 2014
Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM.
PloS one
Assi H,Espinosa J,Suprise S,Sofroniew M,Doherty R,Zamler D,Lowenstein PR,Castro MG
48-5321 was used in Flow cytometry/Cell sorting to evaluate the impact of STAT3 gene ablation on the differentiation of dendritic cells from bone marrow precursors.
Fri Jan 23 00:00:00 UTC 2015
Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM.
PloS one
Assi H,Espinosa J,Suprise S,Sofroniew M,Doherty R,Zamler D,Lowenstein PR,Castro MG
48-5321 was used in Flow cytometry/Cell sorting to evaluate the impact of STAT3 gene ablation on the differentiation of dendritic cells from bone marrow precursors.
Fri Jan 23 00:00:00 UTC 2015
Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.
PloS one
Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu May 28 00:00:00 UTC 2015
Identification of novel thymic epithelial cell subsets whose differentiation is regulated by RANKL and Traf6.
PloS one
Danzl NM,Jeong S,Choi Y,Alexandropoulos K
48-5321 was used in Flow cytometry/Cell sorting to examine the developmental stages of thymic epithelial cells, identifying novel thymic epithelial cell subsets whose differentiation is regulated by RANKL and Traf6.
Wed Oct 29 00:00:00 UTC 2014
Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice.
PloS one
Busch M,Westhofen TC,Koch M,Lutz MB,Zernecke A
48-5321 was used in Flow cytometry/Cell sorting to perform a systematic analysis of dendritic cells and their accumulation characteristics during atherogenesis.
Tue Oct 21 00:00:00 UTC 2014
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Nature immunology
Satpathy AT,Briseño CG,Lee JS,Ng D,Manieri NA,Kc W,Wu X,Thomas SR,Lee WL,Turkoz M,McDonald KG,Meredith MM,Song C,Guidos CJ,Newberry RD,Ouyang W,Murphy TL,Stappenbeck TS,Gommerman JL,Nussenzweig MC,Colonna M,Kopan R,Murphy KM
48-5321 was used in Flow cytometry/Cell sorting to elucidate the cellular source of essential IL-23 production required for the mucosal response to attaching-and-effacing bacterial infection.
Sun Sep 01 00:00:00 UTC 2013
Peripheral elevation of TNF-α leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America
Yang G,Parkhurst CN,Hayes S,Gan WB
48-5321 was used in Flow cytometry/Cell sorting to examine the effect of inflammation and cytokine elevation on synaptic connections in the primary somatosensory cortex in a mouse model of EAE.
Tue Jun 18 00:00:00 UTC 2013
TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity.
The Journal of investigative dermatology
Mohammed J,Gunderson AJ,Khong HH,Koubek RD,Udey MC,Glick AB
48-5321 was used in Immunofluorescence to highlight a role for keratinocyte-derived TGFβ1 in dendritic cell trafficking and in the initiation of skin inflammation.
Tue Jan 01 00:00:00 UTC 2013
SWAP-70 restricts spontaneous maturation of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Ocaña-Morgner C,Götz A,Wahren C,Jessberger R
48-5321 was used in Flow cytometry/Cell sorting to study the mechanisms and signals that produce mature DCs.
Sat Jun 01 00:00:00 UTC 2013
Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Park SY,Jing X,Gupta D,Dziarski R
48-5321 was used in Flow cytometry/Cell sorting to demonstrate the proinflammatory effect of peptidoglycan recognition protein (Pglyrp)1 during the development of allergic asthma.
Mon Apr 01 00:00:00 UTC 2013
A method for high purity sorting of rare cell subsets applied to TDC.
Journal of immunological methods
Kuka M,Ashwell JD
48-5321 was used in Flow cytometry/Cell sorting to describe a customised gating strategy and a sorting protocol for the isolation of T(DC).
Tue Dec 31 00:00:00 UTC 2013
Ulmus davidiana var. japonica Nakai upregulates eosinophils and suppresses Th1 and Th17 cells in the small intestine.
PloS one
Lee HS,Jang MS,Kim JH,Hong CP,Lee EJ,Jeun EJ,Kim C,Kim EK,Ahn KS,Yang BG,Ahn KS,Jang YP,Ahn KS,Kim YM,Jang MH
48-5321 was used in Flow cytometry/Cell sorting to investigate the frequency and cytokine profile of the major immune cells in mice treated orally with UDE.
Sat Aug 02 00:00:00 UTC 2014
Exercise reduces activation of microglia isolated from hippocampus and brain of aged mice.
Journal of neuroinflammation
Kohman RA,Bhattacharya TK,Wojcik E,Rhodes JS
48-5321-82 was used in Flow cytometry/Cell sorting to indicate that running-wheel access modulates microglia activation, but these effects vary by age, sex, and brain region.
Wed Sep 18 00:00:00 UTC 2013
Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages.
Blood
He H,Xu J,Warren CM,Duan D,Li X,Wu L,Iruela-Arispe ML
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Thu Oct 11 00:00:00 UTC 2012
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
48-5321 was used in Flow cytometry/Cell sorting to identify Zbtb46 as a transcription factor selectively expressed by classical DCs and their committed progenitors.
Mon Jun 04 00:00:00 UTC 2012
A TLR and non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade.
Molecular therapy : the journal of the American Society of Gene Therapy
Agudo J,Ruzo A,Kitur K,Sachidanandam R,Blander JM,Brown BD
48-5321 was used in Flow cytometry/Cell sorting to characterise the transient innate immune reaction to lentiviral vector, and evaluate a means for its prevention during LV-mediated gene transfer.
Sat Dec 01 00:00:00 UTC 2012
Preferential colonization of metastases by oncolytic vaccinia virus strain GLV-1h68 in a human PC-3 prostate cancer model in nude mice.
PloS one
Donat U,Weibel S,Hess M,Stritzker J,Härtl B,Sturm JB,Chen NG,Gentschev I,Szalay AA
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunofluorescence
Tue May 07 00:00:00 UTC 2013
Isolation and characterization of novel murine epiphysis derived mesenchymal stem cells.
PloS one
Cheng CC,Lian WS,Hsiao FS,Liu IH,Lin SP,Lee YH,Chang CC,Xiao GY,Huang HY,Cheng CF,Cheng WT,Wu SC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Fri Sep 07 00:00:00 UTC 2012
Activation of Fms-like tyrosine kinase 3 signaling enhances survivin expression in a mouse model of rheumatoid arthritis.
PloS one
Andersson SE,Svensson MN,Erlandsson MC,Dehlin M,Andersson KM,Bokarewa MI
48-5321 was used in Flow cytometry/Cell sorting to study the relationship between survivin levels and Flt3L signalling during rheumatoid arthritis.
Tue Apr 09 00:00:00 UTC 2013
Vesicular stomatitis virus expressing tumor suppressor p53 is a highly attenuated, potent oncolytic agent.
Journal of virology
Heiber JF,Barber GN
48-5321 was used in Flow cytometry/Cell sorting to investigate the potential of p53-incorporating-VSV for the design of VSV therapies and as a basis for VSV-based vaccines.
Sat Oct 01 00:00:00 UTC 2011
Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization.
PloS one
Edelson BT,Bradstreet TR,KC W,Hildner K,Herzog JW,Sim J,Russell JH,Murphy TL,Unanue ER,Murphy KM
48-5321 was used in Flow cytometry/Cell sorting to compare development of peripheral tissue dendritic cells, and susceptibility to experimental autoimmune encephalitis in GM-CSF receptor deficient mice.
Thu Mar 15 00:00:00 UTC 2012
Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection.
Cellular immunology
Pecora ND,Fulton SA,Reba SM,Drage MG,Simmons DP,Urankar-Nagy NJ,Boom WH,Harding CV
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Flow Cytometry
Fri Jan 02 00:00:00 UTC 2009
Infiltration of inflammatory cells plays an important role in matrix metalloproteinase expression and activation in the heart during sepsis.
The American journal of pathology
Cuenca J,Martín-Sanz P,Alvarez-Barrientos AM,Boscá L,Goren N
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 48-5321-82) in Immunohistochemistry
Wed Nov 01 00:00:00 UTC 2006
