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Proteintech
MIB1 Polyclonal Antibody
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Product Details
11893-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MIB1 Fusion Protein Ag2507 (707-1006 aa encoded by BC022403)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LRHHTLSQL RQLQDMQDVG KVDAAWEPSK NTLIMGLGTQ GAEKKSAASI ACFLAANGAD LSIRNKKGQS PLDLCPDPNL CKALAKCHKE KVSGQVGSRS PSMISNDSET LEECMVCSDM KRDTLFGPCG HIATCSLCSP RVKKCLICKE QVQSRTKIEE CVVCSDKKAA VLFQPCGHMC ACENCANLMK KCVQCRAVVE RRVPFIMCCG GKSSEDATDD ISSGNIPVLQ KDKDNTNVNA DVQKLQQQLQ DIKEQTMCPV CLDRLKNMIF LCGHGTCQLC GDRMSECPIC RKAIERRILL Y (707-1006 aa encoded by BC022403)
Target Information
MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DAPK-interacting protein 1; DIP-1; E3 ubiquitin-protein ligase MIB1; Mind bomb homolog 1; RING-type E3 ubiquitin transferase MIB1; ubiquitin ligase mind bomb; Zinc finger ZZ type with ankyrin repeat domain protein 2
Gene Aliases: DIP-1; DIP1; KIAA1323; LVNC7; MIB; MIB1; ZZANK2; ZZZ6
UniProt ID: (Human) Q86YT6
Entrez Gene ID: (Human) 57534
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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