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Invitrogen
MIER3 Polyclonal Antibody
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Product Details
PA5-31879
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human MIER3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.58 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2549352
Product Specific Information
Recommended positive controls: A431.
Predicted reactivity: Mouse (93%), Rat (93%), Chimpanzee (99%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
MIER3, known as Mesoderm Induction Early Response 1, Family Member 3, is a gene associated with epithelial-mesenchymal transition (EMT) processes particularly in cancer research. The gene is located on chromosome 7 and has been identified in studies as playing a crucial role in the progression of colorectal and breast cancers. Structurally, MIER3 is involved in chromatin remodeling and histone acetylation, functioning together with HDAC1/2 and Snail proteins. Its expression profile has been characterized using bioinformatics, real-time PCR, and Western blotting, indicating that MIER3 interacts closely with cellular mechanisms that modulate gene expression and cellular differentiation. The gene's role in cancer has been explored through its capacity to induce EMT, which affects tumor metastasis and cell migration, highlighting its potential as a therapeutic target in oncology.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: mesoderm induction early response 1, family member 3; Mesoderm induction early response protein 3; Mi-er3
Gene Aliases: 5730509D14; AU015422; D130064H19Rik; MIER3; RGD1311241
UniProt ID: (Human) Q7Z3K6, (Mouse) Q3UHF3
Entrez Gene ID: (Human) 166968, (Rat) 310086, (Mouse) 218613
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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