Proteintech

MINA Polyclonal Antibody

MINA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

MINA Antibody (12214-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas cancer using 12214-1-AP (MINA antibody) at dilution of 1:50 (under 10x lens).

MINA Antibody in Immunoprecipitation (IP)

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Product Details

12214-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MINA Fusion Protein Ag2838 (160-465 aa encoded by BC014928)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SLVGSNVYI TPAGSQGLPP HYDDVEVFIL QLEGEKHWRL YHPTVPLARE YSVEAEERIG RPVHEFMLKP GDLLYFPRGT IHQADTPAGL AHSTHVTIST YQNNSWGDFL LDTISGLVFD TAKEDVELRT GIPRQLLLQV ESTTVATRRL SGFLRTLADR LEGTKELLSS DMKKDFIMHR LPPYSAGDGA ELSTPGGKLP RLDSVVRLQF KDHIVLTVLP DQDQSDETQE KMVYIYHSLK NSRETHMMGN EEETEFHGLR FPLSHLDALK QIWNSPAISV KDLKLTTDEE KESLVLSLWT ECLIQVV (160-465 aa encoded by BC014928 )

Target Information

MINA is nuclear localized, myc-inducible protein that is thought to play a role in mammalian cell proliferation. Treatment of cancer cells lines such as the colon cancer cell line SW680 with siRNA against MINA inhibits cell growth, demonstrating that MINA may be a potential therapeutic target. MINA regulates several genes related to cell adhesion and metabolism that have also been shown to be regulated by c-Myc, but also regulates other genes whose expression are not modulated by c-Myc such as EGFR, IL-6 and HGF. MINA has also been found to act as a repressor to IL-4 expression in T cells, indicating that it may also play a role in T cell differentiation and genetic variation in T helper type 2 bias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma.

Cancer research

Zhang L,Huo Q,Ge C,Zhao F,Zhou Q,Chen X,Tian H,Chen T,Xie H,Cui Y,Yao M,Li H,Li J

Mon Jun 15 00:00:00 UTC 2020

Effects of mdig on proliferation and apoptosis of lung cancer cells.

Oncology letters

Xu X,Cao L,Zhang Y,Lian H,Sun Z,Cui Y

Sat Dec 01 00:00:00 UTC 2018

Effects of mdig on proliferation and apoptosis of lung cancer cells.

Oncology letters

Xu X,Cao L,Zhang Y,Lian H,Sun Z,Cui Y

Sat Dec 01 00:00:00 UTC 2018

NFIL3/E4BP4 controls type 2 T helper cell cytokine expression.

The EMBO journal

Kashiwada M,Cassel SL,Colgan JD,Rothman PB

Wed May 18 00:00:00 UTC 2011

NFIL3/E4BP4 controls type 2 T helper cell cytokine expression.

The EMBO journal

Kashiwada M,Cassel SL,Colgan JD,Rothman PB

Wed May 18 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: 60S ribosomal protein L27a histidine hydroxylase; Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; DKFZp762O1912; FLJ14393; Histone lysine demethylase MINA; MINA; mina {ECO:0000312|RGD:708521}; Mina-53; mineral dust induced gene protein; Mineral dust-induced gene protein; MYC-induced nuclear antigen; myc-induced nuclear antigen, 53 kDa; Nucleolar protein 52; Protein mina53; Ribosomal oxygenase 2; Ribosomal oxygenase MINA; ROX

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Gene Aliases: 1810047J07Rik; 2410057H13Rik; 3830408E23Rik; AI449204; MDIG; MINA; MINA53; NO52; RIOX2; ROX

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UniProt ID: (Human) Q8IUF8, (Mouse) Q8CD15, (Rat) Q8CFC1

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Entrez Gene ID: (Human) 84864, (Mouse) 67014, (Rat) 266670

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Function(s)

transcriptional repressor activity, RNA polymerase II transcription factor binding iron ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors sulfonate dioxygenase activity oxidoreductase activity 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity procollagen-proline dioxygenase activity hypophosphite dioxygenase activity DNA-N1-methyladenine dioxygenase activity metal ion binding dioxygenase activity C-19 gibberellin 2-beta-dioxygenase activity C-20 gibberellin 2-beta-dioxygenase activity

Process(es)

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated peptidyl-amino acid modification ribosome biogenesis post-translational protein modification negative regulation of transcription, DNA-templated oxidation-reduction process regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cell proliferation regulation of cell proliferation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MINA Polyclonal Antibody

MINA Antibody (12214-1-AP) in IHC (P)

Product Details

12214-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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