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Proteintech
MIOS Polyclonal Antibody
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Product Details
20826-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MIOS Fusion Protein Ag14802 (526-875 aa encoded by BC005883)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AVALFNLDI RRAIQILNEG ASSEKGDLNL NVVAMALSGY TDEKNSLWRE MCSTLRLQLN NPYLCVMFAF LTSETGSYDG VLYENKVAVR DRVAFACKFL SDTQLNRYIE KLTNEMKEAG NLEGILLTGL TKDGVDLMES YVDRTGDVQT ASYCMLQGSP LDVLKDERVQ YWIENYRNLL DAWRFWHKRA EFDIHRSKLD PSSKPLAQVF VSCNFCGKSI SYSCSAVPHQ GRGFSQYGVS GSPTKSKVTS CPGCRKPLPR CALCLINMGT PVSSCPGGTK SDEKVDLSKD KKLAQFNNWF TWCHNCRHGG HAGHMLSWFR DHAECPVSAC TCKCMQLDTT GNLVPAETVQ P (526-875 aa encoded by BC005883)
Target Information
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ20323; GATOR2 complex protein MIOS; H_DJ1159O04.1; Missing oocyte meiosis regulator homolog; missing oocyte, meiosis regulator, homolog; WD repeat-containing protein mio; WUGSC:H_DJ1159O04.1
Gene Aliases: MIO; MIOS; RGD1308432; Sea4
UniProt ID: (Human) Q9NXC5
Entrez Gene ID: (Human) 54468, (Rat) 362324
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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