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Invitrogen
MIOS Polyclonal Antibody
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Product Details
PA5-65713
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human MIOS. Recombinant protein control fragment (Product #RP-106384).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2664963
Product Specific Information
Immunogen sequence: SISYSCSAVPH QGRGFSQYGV SGSPTKSKVT SCPGCRKPLP RCALCLINMG TPVSSCPGGT KSDEKVDLSK DKKLAQFNNW FTWCHNCRHG GHAGHMLSWF RDHAECPVSA CTCKCMQLD
Highest antigen sequence identity to the following orthologs - mouse 98%, rat 98%.
Target Information
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ20323; GATOR2 complex protein MIOS; H_DJ1159O04.1; Missing oocyte meiosis regulator homolog; missing oocyte, meiosis regulator, homolog; WUGSC:H_DJ1159O04.1
Gene Aliases: MIO; MIOS; Sea4
UniProt ID: (Human) Q9NXC5
Entrez Gene ID: (Human) 54468
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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