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MIP-3 alpha Antibody (MA5-23857) in Neu
Neutralization of MIP-3 alpha in human CCR6. Samples were incubated in MIP-3 alpha monoclonal antibody (Product # MA5-23857). Recombinant Mouse CCL20/MIP‚3α chemoattracts the BaF3 mouse pro‚B cell line transfected with human CCR6 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin. Chemotaxis elicited by Recombinant Mouse CCL20/MIP‚3α (20 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse CCL20/MIP‚3α Monoclonal Antibody... View More
Product Details
MA5-23857
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
114908
Immunogen
E. coli-derived recombinant mouse CCL20/MIP-3 alpha Ala28-Met97
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2609978
Product Specific Information
This antibody does not cross-react with recombinant human (rh) CCL19, rhCCL20, rmCCL3, 4, 9, 19, rmCXCL2, or rrCCL20.
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
Macrophage Inflammatory Protein-3 alpha (MIP-3alpha), also called CCL20, is expressed in the liver, lungs, lymph nodes and peripheral blood lymphocytes. MIP-3alpha is strongly up regulated by inflammatory signals, and down regulated by the anti-inflammatory cytokine IL-10. MIP3alpha signals through the G protein-coupled receptor, CCR6, and acts as a chemoattractant to lymphocytes and dendritic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta chemokine exodus-1; Beta-chemokine exodus-1; C-C motif chemokine 20; CC chemokine LARC; CC chemokine ST38; Liver and activation-regulated chemokine; M-MIP-3-alpha; Macrophage inflammatory protein 3 alpha; MIP 3 a; MIP 3 α; MIP 3alpha; MIP 3α; MIP-3-alpha; MIP3 a; MIP3 alpha; MIP3 α; small inducible cytokine subfamily A20; Small-inducible cytokine A20
Gene Aliases: Ccl20; CKb4; exodus-1; LARC; MIP-3[a]; MIP-3A; MIP3A; Scya20; ST38
UniProt ID: (Mouse) O89093
Entrez Gene ID: (Mouse) 20297
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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