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Chromotek
MK2 VHH Recombinant Alpaca Monoclonal Antibody (CTK0206)
Product Details
MT-250
Product Specifications
Species Reactivity
Hamster,
Human,
Mouse
Host/Isotype
Alpaca
Expression System
E. coli
Class
Recombinant Monoclonal
Type
Antibody
Clone
CTK0206
Immunogen
MK2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
25mM TAPS, pH 8.5, with 5mM EDTA, 500mM NaCl
Contains
0.09% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Wet ice
Product Specific Information
Anti-MK2 Nanobody for conjugation to dyes, beads, plates and surfaces via NHS-chemistry.
Species-Reactivity: Tested on human, mouse, hamster. Posttranslational Modifications: MK2 VHH recognizes unphosphorylated MK2 and Phospho-MK2 (Thr222). Specificity on Phospho-MK2 (Thr334) was not tested.
Target Information
MAPKAPK2 mediates p38 and ERK signaling in vivo. It is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation, and cell proliferation. MAPKAPK2 encodes a member of the Ser/Thr protein kinase family. MAPKAPK2 is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, MAPKAPK2 is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for MAPKAPK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAPK-2; mitogen-activated protein kinase-activated protein kinase 2
Gene Aliases: AA960234; MAPKAP-K2; MAPKAPK2; MK-2; MK2; Rps6kc1
UniProt ID: (Human) P49137, (Mouse) P49138
Entrez Gene ID: (Human) 9261, (Chinese hamster) 100762218, (Mouse) 17164
protein kinase activity
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
signal transducer activity
protein binding
calmodulin binding
ATP binding
calcium-dependent protein serine/threonine kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
mitogen-activated protein kinase binding
MAPK cascade
activation of MAPK activity
toll-like receptor signaling pathway
protein phosphorylation
leukotriene metabolic process
response to stress
inflammatory response
cellular response to DNA damage stimulus
Ras protein signal transduction
peptidyl-serine phosphorylation
G2 DNA damage checkpoint
response to lipopolysaccharide
regulation of interleukin-6 production
regulation of tumor necrosis factor production
response to cytokine
cellular response to vascular endothelial growth factor stimulus
p38MAPK cascade
positive regulation of tumor necrosis factor biosynthetic process
regulation of mRNA stability
macropinocytosis
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
inner ear development
3'-UTR-mediated mRNA stabilization
regulation of cellular response to heat
phosphorylation
mRNA stabilization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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