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Bethyl Laboratories
MKL2 Polyclonal Antibody
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MKL2 Antibody (A302-768A) in IHC (P)
Detection of human MKL2 by immunohistochemistry. Sample: FFPE section of human prostate carcinoma and linitis plastica stomach cancer. Antibody: Affinity purified rabbit anti-MKL2 (Product # A302-768A) (Lot 1) used at a dilution of 1:200 (1 µg/mL) and 1:1,000 (0.2 µg/mL). Detection: DAB.
Product Details
A302-768A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1038 and 1088 of human Megakaryoblastic Leukemia 2.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factors A and B (MRTF-A and MRTF-B) interact with SRF and act as stimulators for its transcriptional activity. MRTF-B is crucial for skeletal myogenic differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTA-276F8.1; gene trap insertion site 4-1; Megakaryoblastic leukemia 2; MKL/myocardin like 2; MKL/myocardin-like 2; MKL/myocardin-like protein 2; MRTF-B; Myocardin-related transcription factor B
Gene Aliases: ENSMUSG00000075401; Gt4-1; KIAA1243; mKIAA1243; MKL2; MRTF-B; MRTFB; NPD001
UniProt ID: (Human) Q9ULH7, (Mouse) P59759
Entrez Gene ID: (Human) 57496, (Mouse) 239719
transcription, DNA-templated
muscle organ development
positive regulation of striated muscle tissue development
positive regulation of transcription from RNA polymerase II promoter
smooth muscle cell differentiation
cell-cell adhesion
in utero embryonic development
liver development
heart morphogenesis
regulation of transcription, DNA-templated
multicellular organism development
heart development
gene expression
regulation of gene expression
cell differentiation
positive regulation of transcription, DNA-templated
blood vessel morphogenesis
embryonic organ development
cardiac muscle tissue development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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