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Invitrogen
MKL2 Monoclonal Antibody (CL1546)
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FIGURE: 1 / 2
MKL2 Antibody (MA5-24628) in ICC/IF
Immunofluorescent staining of MKL2 in A549 cells using MKL2 Monoclonal Antibody (CL1546) (Product # MA5-24628) shows specific staining in nuclear speckles and the cytosol in green. Microtubule and nuclear probes are visualized in red and blue, respectively (where available).
Product Details
MA5-24628
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CL1546
Immunogen
Recombinant protein corresponding to Human MKL2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2637243
Product Specific Information
Immunogen sequence: QRPGPMELVE KNILPVDSSV KEAIIGVGKE DYPHTQGDFS FDEDSSDALS PDQPASQESQ GSAASPSEPK VSESPSPVTT NTPAQFASVS PTVPEFLKTP PTADQPPPRP AAPVLPTNTV SSAKPGPALV KQSHPKNP
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 54%.
Binds to an epitope located within the peptide sequence FASVSPTVPEFLKTP as determined by overlapping synthetic peptides.
Target Information
Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factors A and B (MRTF-A and MRTF-B) interact with SRF and act as stimulators for its transcriptional activity. MRTF-B is crucial for skeletal myogenic differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTA-276F8.1; Megakaryoblastic leukemia 2; MKL/myocardin like 2; MKL/myocardin-like 2; MKL/myocardin-like protein 2; MRTF-B; Myocardin-related transcription factor B
Gene Aliases: KIAA1243; MKL2; MRTF-B; MRTFB; NPD001
UniProt ID: (Human) Q9ULH7
Entrez Gene ID: (Human) 57496
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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