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Abnova
MKNK2 Monoclonal Antibody (2A10)
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Product Details
H00002872-M07
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2A10
Immunogen
MKNK2 (AAH18345, 1 a.a. approximately 158 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MAPEVVEAFS EEASIYDKRC DLWSLGVILY ILLSGYPPFV GRCGSDCGWD RGEACPACQN MLFESIQEGK YEFPDKDWAH ISCAAKDLIS KLLVRDAKQR LSAAQVLQHP WVQGCAPENT LPTPMVLQRW DSHFLLPPHP CRIHVRPGGL VRTVTVNE
Target Information
The Map kinase-interacting kinases (MKNK1 and MKNK2) are activated by Map kinases, regulate protein synthesis by phosphroylation eIF4E on Ser209, and may contribute to tumorigenesis. Overexpression of Mnk2 results in increased phosphorylation of endogenous eIF-4E, showing that it can act as an eIF-4E kinase in vivo. Mnk2 may play a role in the response to environmental stress and cytokines. Expression of active mutants of MNK1 and MNK2 in 293 cells diminishes cap-dependent translation relative to cap-independent translation in a transient reporter assay. Human Mnk2 is homologous to murine Mnk2 (approximately 94% identical) and human Mnk1 (71% identical). In vitro phosphorylation studies show that Mnk2 is a significantly better substrate than Mnk1 for extracellular signal-regulated kinase 2 (Erk2), p38MAPKalpha, and p38MAPKbeta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein-coupled receptor kinase 7; MAP kinase signal-integrating kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2; MAPK signal-integrating kinase 2; mnk2
Gene Aliases: 2010016G11Rik; GPRK7; MKNK2; MNK2
UniProt ID: (Human) Q9HBH9, (Mouse) Q8CDB0, (Rat) Q5U2N4
Entrez Gene ID: (Human) 2872, (Mouse) 17347, (Rat) 299618
regulation of translation
protein phosphorylation
cell surface receptor signaling pathway
peptidyl-serine phosphorylation
hemopoiesis
intracellular signal transduction
protein autophosphorylation
cellular response to arsenic-containing substance
extrinsic apoptotic signaling pathway in absence of ligand
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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