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MKP2 Antibody (PA5-15549) in IHC (P)
Immunohistochemistry analysis of MKP2 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with MKP2 polyclonal antibody (Product # PA5-15549) which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepato... View More
Product Details
PA5-15549
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 331-361 amino acids from the C-terminal region of human DUSP4
Conjugate
Form
Liquid
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2095177
Target Information
DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; DUSP 4; DUSP-4; MAP kinase phosphatase 2; Mitogen-activated protein kinase phosphatase 2; MKP II; MKPII; serine/threonine specific protein phosphatase; VH1 homologous phosphatase 2
Gene Aliases: 2700078F24Rik; AI844617; BB104621; DUSP4; E130306H24Rik; HVH2; MKP-2; MKP2; TYP; VH2
UniProt ID: (Human) Q13115, (Mouse) Q8BFV3
Entrez Gene ID: (Human) 1846, (Mouse) 319520
protein tyrosine phosphatase activity
protein tyrosine/threonine phosphatase activity
phosphatase activity
MAP kinase tyrosine/serine/threonine phosphatase activity
MAP kinase threonine phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine/serine/threonine phosphatase activity
hydrolase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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