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Invitrogen
MKS1 Polyclonal Antibody
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MKS1 Antibody (PA5-30758) in IHC (P)
MKS1 Polyclonal Antibody detects MKS1 protein at cytosol on RT2 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded RT2 xenograft. MKS1 Polyclonal Antibody (Product # PA5-30758) dilution: 1:200. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-30758
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human MKS1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.63 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2548232
Product Specific Information
Recommended positive controls: Jurkat.
Predicted reactivity: Mouse (86%), Rat (85%), Bovine (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene localizes to the basal body and is required for formation of the primary cilium in ciliated epithelial cells. Mutations in this gene result in Meckel syndrome type 1 and in Bardet-Biedl syndrome type 13. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Meckel syndrome type 1 protein; Meckel syndrome type 1 protein homolog; POC12 centriolar protein homolog; Tectonic-like complex member MKS1
Gene Aliases: BBS13; MES; MKS; MKS1; POC12
UniProt ID: (Human) Q9NXB0, (Rat) Q499Q5
Entrez Gene ID: (Human) 54903, (Rat) 287612
neural tube closure
determination of left/right symmetry
epithelial structure maintenance
nonmotile primary cilium assembly
cilium assembly
embryonic digit morphogenesis
embryonic skeletal system development
branching morphogenesis of an epithelial tube
inner ear receptor stereocilium organization
cilium morphogenesis
head development
regulation of canonical Wnt signaling pathway
common bile duct development
regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
motile primary cilium assembly
embryonic brain development
regulation of Wnt signaling pathway, planar cell polarity pathway
regulation of smoothened signaling pathway
motile cilium assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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