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Product Details
25298-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MLH3 Fusion Protein Ag18201 (1190-1430 aa encoded by BC112167)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QVLQQVDNK FIACLMSTKT EENGEADSYE KQQAQGSGRK KLLSSTLIPP LEITVTEEQR RLLWCYHKNL EDLGLEFVFP DTSDSLVLVG KVPLCFVERE ANELRRGRST VTKSIVEEFI REQLELLQTT GGIQGTLPLT VQKVLASQAC HGAIKFNDGL SLQESCRLIE ALSSCQLPFQ CAHGRPSMLP LADIDHLEQE KQIKPNLTKL RKMAQAWRLF GKAECDTRQS LQQSMPPCEP P (1190-1430 aa encoded by BC112167)
Target Information
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DNA mismatch repair protein Mlh3; MGC138372; MutL protein homolog 3
Gene Aliases: HNPCC7; MLH3
UniProt ID: (Human) Q9UHC1
Entrez Gene ID: (Human) 27030
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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