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Product Details
24395-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MLK4 Fusion Protein Ag18904 (689-1036 aa encoded by BC136649)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: WEEAASANA ATVSIEMTPT NSLSRSPQRK KTESALYGCT VLLASVALGL DLRELHKAQA AEEPLPKEEK KKREGIFQRA SKSRRSASPP TSLPSTCGEA SSPPSLPLSS ALGILSTPSF STKCLLQMDS EDPLVDSAPV TCDSEMLTPD FCPTAPGSGR EPALMPRLDT DCSVSRNLPS SFLQQTCGNV PYCASSKHRP SHHRRTMSDG NPTPTGATII SATGASALPL CPSPAPHSHL PREVSPKKHS TVHIVPQRRP ASLRSRSDLP QAYPQTAVSQ LAQTACVVGR PGPHPTQFLA AKERTKSHVP SLLDADVEGQ SRDYTVPLCR MRSKTSRPSI YELEKEFLS (689-1036 aa encoded by BC136649)
Target Information
MLK4 or mixed lineage kinase 4 belongs to the superfamily of MAP kinase kinases (MAP3K1) which contain both ser/thr and tyr kinases activity in their catalytic domains. The structure of this kinase family incorporates an N-terminal Src homology (SH3) domain, followed by the kinase domain, a leucine zipper region, and a CDC42 /RAC -interactive binding (CRIB) motif, but divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas. MLK4 is a negative regulator of TLR4 and does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mitogen-activated protein kinase kinase kinase 21; Mitogen-activated protein kinase kinase kinase MLK4; Mixed lineage kinase 4; MLK4; similar to Mixed lineage kinase 4
Gene Aliases: dJ862P8.3; KIAA1804; MAP3K21; mKIAA1804; MLK4
UniProt ID: (Mouse) Q8VDG6, (Human) Q5TCX8
Entrez Gene ID: (Mouse) 234878, (Human) 84451, (Rat) 307950
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein tyrosine kinase activity
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein binding
protein homodimerization activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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