Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Active Motif
MLL / HRX Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
61295
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This MLL / HRX antibody was raised against a recombinant protein corresponding to amino acids 2829-2883 of human MLL.
Conjugate
Form
Liquid
Concentration
See Datasheet
Purification
Protein A
Storage buffer
PBS, pH 7.5, with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2793585
Target Information
KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', and has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ALL-1; CDK6/MLL fusion protein; CXXC-type zinc finger protein 7; Cysteine methyltransferase KMT2A; Histone-lysine N-methyltransferase 2A; histone-lysine N-methyltransferase MLL; lysine (K)-specific methyltransferase 2A; Lysine N-methyltransferase 2A; mixed lineage leukemia 1; MLL-AF4 der(11) fusion protein; MLL/ENL fusion protein; MLL/GAS7 fusion protein; MLL/GMPS fusion protein; MLL/hCDCrel fusion protein; Myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia 1; Myeloid/lymphoid or mixed-lineage leukemia protein 1; rearranged MLL protein; trithorax Drosophila; Trithorax-like protein; Zinc finger protein HRX
Gene Aliases: 6430520K01; ALL-1; ALL1; CXXC7; HRX; HTRX; HTRX1; KMT2A; mKIAA4050; MLL; MLL-AF9; MLL/GAS7; MLL1; MLL1A; TET1-MLL; TRX1; WDSTS
UniProt ID: (Human) Q03164
Entrez Gene ID: (Human) 4297, (Mouse) 214162
core promoter sequence-specific DNA binding
AT DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
histone-lysine N-methyltransferase activity
histone methyltransferase activity (H3-K4 specific)
identical protein binding
protein homodimerization activity
transcription regulatory region DNA binding
unmethylated CpG binding
lysine-acetylated histone binding
DNA binding
methyltransferase activity
transferase activity
metal ion binding
DNA methylation
transcription, DNA-templated
regulation of transcription, DNA-templated
protein complex assembly
negative regulation of cell proliferation
anterior/posterior pattern specification
chromatin modification
methylation
positive regulation of transporter activity
circadian regulation of gene expression
embryonic hemopoiesis
histone H4-K16 acetylation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
histone H3-K4 methylation
regulation of histone H3-K4 methylation
positive regulation of histone H3-K4 methylation
regulation of histone H3-K14 acetylation
histone H3-K4 trimethylation
regulation of histone H3-K9 acetylation
positive regulation of cellular response to drug
transcription from RNA polymerase II promoter
apoptotic process
visual learning
post-embryonic development
peptidyl-lysine monomethylation
exploration behavior
response to potassium ion
histone H3-K4 dimethylation
regulation of short-term neuronal synaptic plasticity
spleen development
homeostasis of number of cells within a tissue
membrane depolarization
definitive hemopoiesis
regulation of histone H3-K27 acetylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support