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Proteintech
MLN51/CASC3 Polyclonal Antibody
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Product Details
18047-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MLN51/CASC3 Fusion Protein Ag12694 (354-703 aa encoded by BC050526)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LEQTSVRDP SPEADAPVLG SPEKEEAASE PPAAAPDAAP PPPDRPIEKK SYSRARRTRT KVGDAVKLAE EVPPPPEGLI PAPPVPETTP TPPTKTGTWE APVDSSTSGL EQDVAQLNIA EQNWSPGQPS FLQPRELRGM PNHIHMGAGP PPQFNRMEEM GVQGGRAKRY SSQRQRPVPE PPAPPVHISI MEGHYYDPLQ FQGPIYTHGD SPAPLPPQGM LVQPGMNLPH PGLHPHQTPA PLPNPGLYPP PVSMSPGQPP PQQLLAPTYF SAPGVMNFGN PSYPYAPGAL PPPPPPHLYP NTQAPSQVYG GVTYYNPAQQ QVQPKPSPPR RTPQPVTIKP PPPEVVSRGS S (354-703 aa encoded by BC050526)
Target Information
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: barentsz; Btz; Cancer susceptibility candidate gene 3 protein; metastatic lymph node 51; Metastatic lymph node gene 51 protein; MLN 51; Protein barentsz; Protein CASC3
Gene Aliases: BTZ; CASC3; MLN51
UniProt ID: (Human) O15234
Entrez Gene ID: (Human) 22794
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
mRNA splicing, via spliceosome
termination of RNA polymerase II transcription
RNA export from nucleus
mRNA export from nucleus
regulation of translation
biological_process
intracellular mRNA localization
RNA metabolic process
mRNA 3'-end processing
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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